中西医结合治疗口腔黏膜下纤维化的疗效  

Therapeutic effect of the combination of traditional Chinese medicine and western medicine on patients with oral submucous fibrosis

作　　者：吴颖芳[1] 彭解英[2] 阙国鹰[1] 许春姣[2] 尹晓敏[1] 

机构地区：[1]中南大学湘雅医院口腔科,长沙410008 [2]中南大学口腔医学院牙周黏膜病学教研室,长沙410078

出　　处：《中南大学学报（医学版）》2010年第4期358-364,共7页Journal of Central South University ：Medical Science

基　　金：湖南省教育发展基金[湘教发(2005)100号]~~

摘　　要：目的:观察并比较丹参与泼尼松龙两者合用及单独使用泼尼松龙治疗口腔黏膜下纤维化的临床疗效。方法:选取口腔黏膜下纤维化初诊患者中、晚期各60例,各随机分为两组,分别采用丹参联合泼尼松龙(第1组)及单独使用泼尼松龙(第2组)治疗3个月,比较用药前、后患者病损面积、张口度和疼痛指数的变化,比较两治疗方案的临床疗效。结果:治疗3个月后,第1组口腔黏膜下纤维化中期和晚期患者的灰白色病损面积分别由(10.37±3.40)cm2和(19.60±3.27)cm2减少为(5.90±4.10)cm2和(16.33±4.02)cm2,中晚各期治疗前后比较,差异有统计学意义(P<0.05);张口度分别由(3.41±0.77)cm和(1.98±0.39)cm增加为(3.87±0.67)cm和(2.26±0.46)cm,中晚各期治疗前后比较,差异有统计学意义(P<0.05)。第2组治疗后中期患者的灰白色病损面积由(10.87±3.18)cm2减少为(6.70±3.75)cm2,张口度由(3.57±0.75)cm增加为(3.97±0.69)cm,治疗前后比较,差异均有统计学意义(P<0.05);而晚期治疗前后比较,其灰白色病损面积和张口度差异均无统计学意义(P>0.05)。两种方法治疗中期口腔黏膜下纤维化有效率分别为86.66%和73.33%,2组比较差异无统计学意义(P>0.05);而2种方法治疗口腔黏膜下纤维化晚期的有效率分别为70%和16.67%,2组比较有统计学差异(P<0.05)。丹参与泼尼松龙联合用药治疗口腔黏膜下纤维化,还可减少泼尼松龙引起的不良反应。结论:丹参联合泼尼松龙治疗口腔黏膜下纤维化具有明显优势。Objective To observe the therapeutic effect of salvia miltiorrhiza and prednisolone on patients with oral submucous fibrosis （OSF）.Methods A total of 60 medium-term OSF patients and 60 advanced stage OSF patients were randomly divided into the first group （treated with both salvia miltiorrhiza and prednisolone） and the second group （treated with prednisolone alone）.The clinical effect was compared between each group after 3-month treatment.Results Difference was found in the lesion area of the medium-term cases and the advanced stage cases of the first group before the treatment [（10.37±3.40） cm^2,（19.60±3.27） cm^2] and after the treatment [（5.90±4.10） cm^2,（16.33±4.02） cm^2] （P〈0.05）.Significant difference was found in the mouth opening before the treatment [（3.41±0.77） cm,（1.98±0.39） cm] and after the treatment [（3.87±0.67） cm,（2.26±0.46） cm] （P〈0.05） in the first group.There was significant difference in the lesion area and mouth opening of the medium-term cases of the second group before the treatment [（10.87±3.18） cm^2,（3.57±0.75） cm] and after the treatment [（6.70±3.75） cm^2,（3.97±0.69） cm] （P〈0.05）.No difference in the lesion area and mouth opening of the advanced stage cases of the second group was found （P〉0.05）.There was difference in the therapeutic efficacy between the first group （70%） and the second group （16.67%） of the advanced stage cases （P〈0.05）,but not in the clinical effect between the 2 groups of the medium-term cases （P〉0.05）.The side effect of prednisolone could be reduced while used together with salvia miltiorrhiza.Conclusion There is obvious advantage in treating OSF by the combination of salvia miltiorrhiza and prednisolone.

关 键 词：口腔黏膜下纤维化 治疗 丹参 泼尼松龙 

分 类 号：R781.5[医药卫生—口腔医学]