膀胱内灌注盐酸表柔比星预防膀胱癌术后复发92例临床对照研究  

Post-operation intrarestical instillation of epirubicin hydrochloride to prevent recurrence of bladder cancer(report of 92 cases)

作　　者：张明[1] 刘秋菊[2] 魏巍[1] 王颂[1] 张丹 

机构地区：[1]吉林大学第二医院泌尿外科,吉林长春130041 [2]吉林大学第二医院血液科,吉林长春130041 [3]东辽人民医院泌尿外科,吉林东辽136200

出　　处：《现代泌尿外科杂志》2010年第3期171-172,共2页Journal of Modern Urology

摘　　要：目的研究盐酸表柔比星膀胱灌注预防经尿道膀胱癌电切术(TURBt)术后复发的疗效。方法对184例膀胱癌患者在TVRBt术后行膀胱灌注化疗,平均分成两组:Ⅰ组(92例)定期膀胱内灌注盐酸表柔比星,术后第1天使用50 mg,膀胱内灌注保留2 h,1周后开始常规灌注化疗,每周1次连续3次,然后每月1次连续11次,共1年;Ⅱ组(92例)为对照组灌注丝裂霉素40mg,灌注方法同Ⅰ组。结果随访10～46个月,平均(30±4)个月。复发率Ⅰ组为6.5%,Ⅱ组为17.4%,差异有统计学意义(P<0.05);不良反应包括尿路刺激症状、肉眼血尿等,两组比较差异无统计学意义。结论 TURBt后早期膀胱内灌注盐酸表柔比星化疗,可以显著降低膀胱肿瘤复发率。Objective To study the efficacy of intravesical instillation of epirubicin hydrochloride in prophylaxis of recurrence after transure thral resection of bladder tumor （TURBt）. Methods Intravesical instillation of epirubicin hydrochloride was used in 184 patients for prophylaxis of recurrence after （TURBt）. The patients were divided into two groups. Group I ： 50 mg epirubicin hydrochloride was instilled into bladder and retained for 2 hours the first day after operation. The instillation was performed once a week for 3 weeks, and then once a month for 11 months. Group II：30mg mitomycin was perfused with the same methed as in Group I . Results The patients were followed up for 10-46 months, average（30± 4） months. The recurrence rate were 6.5% and 17.4% in Group I and Group II respeetinely,which had statistical significance（P 〈0.05）. Conclusion Intravesical instillation of epirubicin hydrochloride is safe and effective in preventing local recurrence of bladder cancer after TURBt.

关 键 词：膀胱癌 盐酸表柔比星 膀胱灌注 

分 类 号：R737[医药卫生—肿瘤]