肝细胞癌SCT征象与VEGF表达关系的研究  

Correlative study of SCT features and expressions of VEGF protein in hepatocellular carcinoma

作　　者：陆晓旻[1] 彭春[1] 

机构地区：[1]河南省焦作市人民医院病理科,焦作454000

出　　处：《陕西医学杂志》2010年第5期613-615,共3页Shaanxi Medical Journal

摘　　要：目的:探讨肝细胞癌(HCC)SCT征象与肿瘤血管生成因子VEGF表达的关系。方法:对42例(45个病灶)经手术病理证实且行SCT动、静脉双期增强扫描的HCC病例,观察每个癌灶的SCT表现特征:肿瘤的大小、包膜、侵袭危险性、强化类型和肝硬化情况。用免疫组织化学的方法检测癌组织中血管生成因子VEGF的表达情况。结果:SCT图像上HCC肿瘤大小、侵袭危险性、强化类型分别与VEGF表达之间有相关性(P<0.05),HCC包膜形成状态和癌灶周围组织有无肝硬化与VEGF蛋白表达之间无相关性(P>0.05)。结论:HCC的SCT表现与VEGF表达存在较为密切的相关关系,根据HCC的SCT表现特征(肿瘤大小、侵袭危险性、强化类型),可在一定程度上预测VEGF表达情况,有助于HCC的诊断、治疗及预后判断。Objective：To investigate the correlations of SCT（spiral CT）appearances and the expressions of VEGF in HCC（hepatocellular carcinoma）.Methods：Enhancement dualphase（arterial phase and portal vein phase）of SCT scanning was performed in 42 patients（45 lesions）of HCC confirmed histopathologically.The expressions of VEGF in tumor specimens were detected with immunohistochemical SP method.The relations between the features of HCC on SCT and the expressions of VEGF proteins were analyzed.Results：Tumor size,infiltration and severity,enhancement type on SCT image had significantly correlations with VEGF protein,respectively（P0.05）.But there were no relations between pseudocapsula,hepatic cirrhosis and VEGF.Conclusion：The SCT imaging of HCC（tumor size,infiltration and severity,enhancement style）can indicate the expressions of VEGF to some extent.It will benefit the early diagnosis and selection of therapy planning.

关 键 词：肝肿瘤/放射照相术 体层摄影术 X线计算机 肝肿瘤/病理学 

分 类 号：R735.7[医药卫生—肿瘤]