食管鳞癌组织中PTEN的表达及其临床意义  

Expression of PTEN in esophageal squamous cell carcinoma ( ESCC) and its clinical significance

作　　者：黄绮国[1] 倪仰鹏[1] 陈蔓[1] 谢丽霞[1] 

机构地区：[1]揭阳市人民医院病理科,522000

出　　处：《中国实用医药》2010年第15期34-35,共2页China Practical Medicine

摘　　要：目的观察PTEN在食管鳞癌组织当中的表达,探讨其与食管鳞癌发生的联系及其临床意义。方法应用免疫组化S-P法检测食管鳞癌组织、癌旁正常食管组织中PTEN的蛋白表达情况。结果 PTEN在正常食管黏膜和食管癌中阳性率分别为96.4%,65.5%。PTEN表达与食管癌的分化程度高低、浸润深度、是否有淋巴结转移和临床分期关系密切(P<0.05),与患者年龄、性别无关(P>0.05)。结论 PTEN蛋白异常表达在食管鳞癌发生发展过程中有重要作用。Objective To investigate the protein expression and its significance of tumor suppressor gene PTEN in esophageal squamous cell carcinoma （ ESCC） . Methods Immunohistochemical staining S-P method was used to determine the expression of PTEN in ESCC and the normal esophageal tissues （ NET） which were adjacent to the carcinoma. Results The positive rate of expression of PTEN p rotein in NET and ESCC were 96.4% and 65.5%. Expression of PTEN in ESCC was related with expression of lymph node matastais , differention , TNM stage , tumor invasion （ P〈0. 05） , and no relationship with the patients’age and gender （ P〉0. 05）. Conclusion It is suggested that PTEN can be an objective marker for its pathological and biological behaviors of esophageal squamous cell carcinoma.

关 键 词：食管鳞癌 PTEN 蛋白表达 

分 类 号：R735.1[医药卫生—肿瘤]