Metacaspase在酵母凋亡过程中的作用  

Role of Metacaspase in Yeast Apoptisis Progress

作　　者：卢丽[1] 冯霞[1] 徐婷婷[1] 李树峰[1] 佟慧丽[1] 严云勤[1] 

机构地区：[1]东北农业大学生命科学学院,黑龙江哈尔滨150030

出　　处：《现代农业科技》2010年第8期36-38,40,共4页Modern Agricultural Science and Technology

摘　　要：Metacaspase是由YCA1/MCA1编码的一种哺乳动物caspases同系物。由于其分子结构的差异,使其断裂为不同的特异性底物。在哺乳动物中,凋亡被一组蛋白酶caspases定向激活,断裂特异性底物且触发细胞死亡。环境损伤、细胞内缺陷、预凋亡基因的异源表达诱导具有典型凋亡特征的酵母细胞死亡与metacaspase紧密相关。删除metacaspase可以阻碍不同因素引起的死亡,metacaspase在酵母细胞凋亡中具有核心作用。Metacaspase is a kind of mammal caspases homolog which coded by the YCA1/MCA1 gene.It can break into different specificity substrates because its difference in molecular structure.In mammals,apoptosis can be activated directly by a group of proteases,called caspases,then cleave specific substrates and trigger cell death.Damaging environment,certain intracellular defects and heterologous expression of pro-apoptotic genes inducing death in yeast cells exhibiting typical markers of apoptosis was closely related with the metacaspase.Metacaspase deletion may hinder the death which was caused by different factors.Metacaspase played a central role in yeast apoptosis progress.

关 键 词：酵母 YCA1 凋亡 

分 类 号：Q255[生物学—细胞生物学]