1,5-苯并硫氮杂-β-内酰胺的合成及其副产物的研究  

Synthesis and By-products Studies of β-Lactam Derivatives of 1,5-Benzothiazepine

作　　者：张萍[1] 杜彩云[2] 王兰芝[1] 李媛[1] 

机构地区：[1]河北师范大学化学与材料科学学院,石家庄050016 [2]河北工程大学理学院,邯郸056038

出　　处：《有机化学》2010年第5期731-734,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No20972040);河北省自然科学基金(NoB2007000239)资助项目

摘　　要：以3-(3S-叔丁氧基)丁二酰亚胺基乙酰氯作为烯酮的来源,和1,5-苯并硫氮杂反应合成了4个具有光学活性的新型1,5-苯并硫氮杂-β-内酰胺衍生物.通过1HNMR,IR,MS谱和元素分析对其结构进行了表征,在得到目标产物的同时还得到了该反应的另外两个副产物,并且通过单晶X射线衍射确定了这两个副产物的结构.Four new β-lactam derivatives of 1,5-benzothiazepine were obtained by the reaction of 3- （3S-t-butoxyl）succinimidyl acetyl chloride with 1,5-benzothiazepines and their structures were confirmed by ^1H NMR, IR, MS techniques and elemental analysis. The other two products of this reaction were also obtained, and their structures were determined by X-ray diffraction analyses methods.

关 键 词：1 5-苯并硫氮杂 [艹卓] Β-内酰胺 晶体结构 

分 类 号：R914[医药卫生—药物化学]