晚期胃肠癌术后辅助化疗的临床研究  

Clinical Control Study on Subsidiary Chemotherapy of Advanced Gastrointestinal Caner after Operation

作　　者：于虹娥[1] 鲍振华[1] 张金梅[1] 

机构地区：[1]青岛大学医学院附属医院海阳分院,265100

出　　处：《实用癌症杂志》2010年第3期283-285,共3页The Practical Journal of Cancer

摘　　要：目的比较奥沙利铂联合亚叶酸钙、替加氟方案与奥沙利铂联合亚叶酸钙、氟尿嘧啶方案治疗术后晚期胃肠道肿瘤的临床疗效和不良反应。方法将67例晚期胃肠道肿瘤患者,随机分为A、B两组,A组42例,奥沙利铂,130mg/m2,持续静脉点滴2h,d1;亚叶酸钙,150mg/m2,静脉点滴,d1～5;替加氟,1.0g,静脉点滴,d1～5,3周后重复。B组25例,奥沙利铂,130mg/m2,持续静脉点滴2h,d1;亚叶酸钙,150mg/m2,静脉点滴,d1～5;氟尿嘧啶,300mg/m2,静脉持续输注6h,d1～5,3周后重复。治疗2个周期后比较不良反应。结果 2年生存率A组(52.4%)高于B组(48.0%),但两组比较差异无统计学意义(P>0.05)。两组重度不良反应A组少于B组,差异有统计学意义(P<0.05),其中重度骨髓抑制、重度肝肾功能损害两组比较差异无统计学意义(P>0.05),而重度腹泻、重度口腔炎及重度恶心、呕吐两组比较均有统计学意义(P<0.05)。结论替加氟代替氟尿嘧啶联合奥沙利铂及亚叶酸钙治疗晚期胃肠道肿瘤,不良反应轻、安全简便、易行。Objective To evaluate and compare the efficacy and safety between the chronomodulated chemotherapy of oxaliplatin combined with calcium folinate and tegafur and the normal chemotherapy in the treatment of advanced gastrointestinal cancer after operation.Methods A total of 67 patients with advanced gastrointestinal cancer were randomly divided into group A of 42 and group B of 25.Regimen of group A was：OXA 130 mg/m2 iv.drip 2hrs.;CF 150 mg/m2 iv,drip followed by tegafur 1.0,d1~5,repeated every 3 weeks.That of group B：OXA 130 mg/m2 iv.drip 2hrs.;CF 150 mg/m2 iv.drip followed by 5-Fu 300 mg/m2 c.i.v.6hrs.d1~5,also repeated every 3 weeks.Efficacy and toxicity were evaluated after 2 cycles.Results The anosis survival rate in 2 years of group A and group B were 52.4%（23/42）and 48.0%（12/25）,respectively.The two groups had no significant difference（P0.05）.Grade 3 or 4 toxicities were significantly different between the two groups（P0.05）.Grade 3 or 4 myelosuppression and the damage of the liver and kidney were little different between the two groups（P0.05）.While grade 3 or 4 diarrhea,stomatitis and vomiting were significantly different between the two groups（P0.05）.Conclusion Tegafur instead of 5-Fu combined with OXA/CF to treat patients with advanced gastrointestinal cancer was simple,available,effective and with more little toxicity.

关 键 词：胃肠道肿瘤 奥沙利铂 亚叶酸钙 替加氟 氟尿嘧啶 

分 类 号：R735.2[医药卫生—肿瘤] R735.3[医药卫生—临床医学]