嗅觉障碍检测对轻度认知功能损害诊断价值的研究  

Diagnostic value of mild cognitive impairment with dysosmia detection

作　　者：胡庆东[1] 牛利华[1] 唐敏[2] 唐发霞[2] 李光武[1] 

机构地区：[1]安徽医科大学神经生物学研究所,安徽合肥230032 [2]合肥市第一人民医院神经内科,安徽合肥230061

出　　处：《安徽医药》2010年第6期671-672,共2页Anhui Medical and Pharmaceutical Journal

基　　金：中国博士后基金(No20060400201);安徽省自然科学基金(No090413145);合肥市科技局重点科研项目(No20081006)

摘　　要：目的探讨在中老年(50岁以上)人群中嗅觉障碍检测对轻度认知功能损害诊断的价值。方法运用简易智能状态检查(MMSE)对研究人群进行认知功能检查,根据MMSE结果将受试人群分为可能MCI组(n=19)和正常对照组(n=46)。采用气味感知阈试验、气味识别试验、气味再记忆试验等对受试者进行嗅觉功能检测。结果可能MCI组的气味感知阈值(P<0.01)、气味识别(P<0.01)和气味再记忆功能(P<0.05)较正常对照组差;相关分析显示,MMSE总分与气味识别之间有显著的相关性(r=0.299,P<0.05)。结论 MCI患者存在嗅觉功能损害,嗅觉障碍是MCI的简单反映;嗅觉的气味识别可以作为早期筛查认知功能损害的方法之一。Aim To explore on diagnostic value of mild cognitive impairment with dysosmia detection in elderly population（50 years and older）.Methods Mini-mental state examination（MMSE）was used to evaluate the cognitive abilities for study population.According to MMSE results,subjects were divided into possible MCI group（n=19）and normal control group（n=46）.Determination of odor perception threshold,odor identification test and odor memory test were exploited to detect the olfactory functions.Results Compared with normal control group,odor perception threshold,odor identification（P〈0.01）and odor memory function（P〈0.05）of possible MCI group are even worse.Correlation analysis showed that MMSE total score had significant correlation with odor identification（r=0.299,P〈0.05）.Conclusion As expected,MCI.patients have olfactory dysfunction.Olfactory dysfunction may simply reflect MCI.Odor identification of olfaction can be used as a simple way to estimate cognitive impairments in elderly population.

关 键 词：轻度认知损害 简易智能状态检查 嗅觉功能 嗅觉通路 

分 类 号：R749.1[医药卫生—神经病学与精神病学]