The Nucleolus and Viral Infection  

作　　者：Lei WANG Xiao-ming REN Jun-ji XING Alan C. ZHENG 

机构地区：[1]State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China [2]The Department of Animal Science, Beijing University of Agriculture, Beijing 102206, China

出　　处：《Virologica Sinica》2010年第3期151-157,共7页中国病毒学（英文版）

基　　金：The Startup Fund of the Hundred Talents Program of the Chinese Academy of Science (20071010141);National Natural Science Foundation of China(30870120);Open Research Fund Program of the State Key Laboratory of Virology of China (2007003, 2009007);Hubei Province Natural Science Foundation of Innovation Groups Project (2008CDA013)

摘　　要：The nucleolus is a subnuclear structure of eukaryocytes. It was thought that nucleolus only participates in the biogenesis and processing of rRNA. However, more and more evidence shows that it has many other functions, such as tRNA precursor processing, stress sensing and it is also involved in gene silencing, senescence and cell cycle regulation. Here, we summarize the recent understandings about the nucleolar functions, the regulation of nucleolar localization of proteins and the role that the nucleolus plays in virus infection, in which some related studies of Herpes simplex virus type 1 (HSV-1) US11, UL24 and bovine herpesvirus-1 infected cell protein 27 (BICP27) carried out in our lab will also be included.The nucleolus is a subnuclear structure of eukaryocytes. It was thought that nucleolus only participates in the biogenesis and processing of rRNA. However, more and more evidence shows that it has many other functions, such as tRNA precursor processing, stress sensing and it is also involved in gene silencing, senescence and cell cycle regulation. Here, we summarize the recent understandings about the nucleolar functions, the regulation of nucleolar localization of proteins and the role that the nucleolus plays in virus infection, in which some related studies of Herpes simplex virus type 1 （HSV-1） US 11, UL24 and bovine herpesvirus-1 infected cell protein 27 （BICP27） carried out in our lab will also be included

关 键 词：NUCLEOLUS STRESS Cell cycle regulation Virus infection. 

分 类 号：Q753[生物学—分子生物学] S858.28[农业科学—临床兽医学]