CYP1和COMT介导的雌二醇代谢与乳腺癌的关系及相关抗癌药的研发思路  

Relationship of CYP1-and COMT-mediated Estradiol Metabolism with Breast Cancer and the Related Anti-cancer Drug Design

作　　者：杨文亮[1] 柳晓泉[1] 

机构地区：[1]中国药科大学药物代谢动力学研究中心,江苏南京210009

出　　处：《药学进展》2010年第5期202-209,共8页Progress in Pharmaceutical Sciences

摘　　要：雌二醇代谢在乳腺、子宫和卵巢等雌激素相关器官以及肿瘤组织内主要由细胞色素P450酶1(CYP1)和儿茶酚甲基转移酶(COMT)所介导。这两种酶与乳腺癌的发生发展密切相关,可作为抗癌药的靶点加以开发利用。综述雌二醇代谢中CYP1和COMT的作用及其与乳腺癌的关系,介绍相关的抗肿瘤药物的研发。Estradiol metabolism was predominantly mediated by cytochrom P450 1 （CYP1） and catecbol O-methyltransferase （COMT） in estrogen-regulated organs and tissues including breast, uterus, ovary and tumor tissues. Both the enzymes may play a significant role in breast cancer risk. In this paper, the CYP1- and COMT-mediated metabolism of estradiol and their relationship with the risk of breast eaneer were reviewed and the related anti-cancer drugs design was introduced.

关 键 词：雌二醇代谢 细胞色素P450酶1 儿茶酚甲基转移酶 乳腺癌 新药研发 

分 类 号：R737.9[医药卫生—肿瘤]