垂体后叶素联合硝酸甘油治疗食管胃底静脉曲张破裂出血的疗效观察  

The effect observation of pituitrin and nitroglycerin treated for esophageal and gastric bottom varicosity bleeding

作　　者：陈菊[1] 

机构地区：[1]四川省凉山彝族自治州第一人民医院马道分院,615031

出　　处：《临床合理用药杂志》2010年第9期15-16,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察垂体后叶素联合硝酸甘油治疗食管胃底静脉曲张破裂出血的疗效。方法将肝硬化食管胃底静脉曲张破裂出血患者90例随机分为3组,各30例。A组给予垂体后叶素0.2U/min及硝酸甘油25～50μg/min静脉滴注;B组先给予善宁100μg加5%葡萄糖注射液20ml中静脉推注,后给予25μg/h维持;C组给予垂体后叶素,用法同A组。比较3组临床疗效及不良反应。结果 3组止血时间和止血成功率两两相比,差异无统计学意义(P>0.05)。A组不良反应5例(16.7%),B组发生不良反应4例(13.3%),C组发生不良反应15例(50.0%)。A、B组与C组不良反应发生率比较,差异有统计学意义(P<0.01)。结论垂体后叶素联合硝酸甘油治疗食管胃底静脉曲张破裂出血疗效确切、不良反应少、价格低廉,在临床上尤其是基层医院仍有广泛使用的意义。Objective To observe the effect of pituitrin and nitroglycerin treated for esophageal gastric bottom varicosity bleeding. Methods 90 cases patients were divided into three groups,each of 30 cases. Group A were gave pituitrin 0. 2U/min and nitroglycerin 25 ～ 50μg/min infusion;Group B were gave sandostatin 100μg add 5% GS 20ml infusion,after that sandostatin 25μg/h infusion;Group C were gave pituitrin 0. 2U/min infusion. The clinical efficacy and adverse reactions of 3 groups were compared. Results Compared hemostasis time and hemostasis success rate of 3 group,the difference were not statistically significant（P 0. 05）. Adverse reactions of A group had 5 cases（16. 7% ）,B group had 4 cases（13. 3% ）,C group had 15 cases（50. 0% ）. But the adverse reactions incidence of A,B and C group,the difference were statistically significant（P 0. 01）. Conclusion Vasopressin combined with nitroglycerin treated for esophageal variceal bleeding is effective,less side,low cost,clinically,especially primary hospital is still widely used significance.

关 键 词：垂体后叶素 硝酸甘油 醋酸奥曲肽 食管胃底静脉曲张 

分 类 号：R575.2[医药卫生—消化系统]