口腔癌中肿瘤坏死因子-α的表达与巨噬细胞关系的研究  

The relationship between tumor necrosis factor-α and macrophage in oral squamous cell carcinoma

作　　者：杨建斌[1] 邵月保[1] 魏东义[1] 马敬斋[1] 冯红超[2] 宋宇峰[2] 

机构地区：[1]新乡医学院第一附属医院口腔科,河南卫辉453100 [2]贵阳医学院附属医院口腔科

出　　处：《现代口腔医学杂志》2010年第3期205-207,共3页Journal of Modern Stomatology

基　　金：贵州省第二批跨世纪人才省政府专项基金-黔科合人专字(2000)9813号

摘　　要：目的探讨口腔鳞状细胞癌中肿瘤坏死因子-α(tumornecrosis factor-α,TNF-α)表达与肿瘤中浸润巨噬细胞的关系。方法应用免疫组化的方法检测口腔鳞癌中TNF-α的表达和巨噬细胞的浸润,光镜进行高倍视野下巨噬细胞记数和TNF-α表达的分级。结果在口腔鳞癌中TNF-α的表达与肿瘤分化有关,并与肿瘤内浸润的巨噬细胞有关(P<0.05)。结论口腔癌中浸润进入肿瘤的巨噬细胞可能受TNF-α趋化作用的影响,参与肿瘤的生长和转移。Objective To study the relationship between tumor necrosis factor-α（TNF-α）expression and macrophage infiltration and recruitment in oral squamous cell carcinoma （OSCC）.Methods The scores of macrophages and grade of TNF-αexpression were detected with light microscopes after immunohistochemical SABC staining.Results TNF-αexpression was related to the differentiation of OSCC and macrophage infiltration in carcinoma （P0.05）.Conclusion Macrophage infiltration influenced by TNF-αchemotaxis might be involved in the growth and metastasis of OSCC.

关 键 词：口腔 癌 鳞状细胞 巨噬细胞 肿瘤坏死因子-Α 

分 类 号：R739.8[医药卫生—肿瘤]