单个核细胞分化的命运与动脉粥样硬化  

Differentiated fate of mononuclear cells and atherosclerosis

作　　者：杨娜娜[1] 张良[2] 丁国勇[3] 桑慧[1] 秦树存[1] 

机构地区：[1]泰山医学院动脉粥样硬化研究所,山东泰安271000 [2]泰山医学院临床医学系,山东泰安271000 [3]泰山医学院医学检验与预防医学系预防医学教研室,山东泰安271000

出　　处：《中国病理生理杂志》2010年第5期1015-1019,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.30971098);山东省自然科学基金资助项目(No.Z2008C03)

摘　　要：动脉粥样硬化（atherosclerosis,AS）是危害人类健康最严重的心脑血管疾病之一,故阻止AS的进展已成为基础医学与临床医学研究的热点。AS以血管平滑肌细胞增生、脂质沉积形成粥样硬化斑块为特征,并伴有炎症性疾病的病理现象,如变质。Mononuclear cells（MNCs） isolatedfrommammal＇sbonemarrowandperipheral bloodbymeansof Ficoll density grandient centrifugation,which are composed of monocytes and lymphocytes,can differentiate into different progenitor cells with different functions in the development of atherosclerosis under different inducing conditions. This article described the induction conditions of MNCs,the identification methods of different progenitor cells,and the relationship between these progenitor cells and the development of atherosclerosis,thus provide a new idea for the prevention of the atherosclerosis.

关 键 词：动脉硬化 单核细胞 内皮祖细胞 树突细胞 

分 类 号：R363[医药卫生—病理学]