胃癌根治术中腹腔冲洗液脱落细胞学对比研究  

Comparative Study on the Peritoneal Lavage Cytology during Radical Resection of Gastric Cancer

作　　者：刘宏斌[1] 刘振芳[1] 韩晓鹏[1] 朱万坤[1] 苏琳[1] 

机构地区：[1]兰州军区兰州总医院普外科,730050

出　　处：《医学研究杂志》2010年第5期39-41,124,共4页Journal of Medical Research

基　　金：全军"十一五"计划面上项目资助(06MA082)

摘　　要：目的研究胃癌根治术中腹腔多次冲洗对于降低患者腹腔内脱落癌细胞阳性率的临床意义。方法对160例胃癌患者术中行多次腹腔冲洗,肿瘤切除前1次,切除后3次。将4次腹腔冲洗液行常规病理学涂片细胞学检查,结果进行对比。结果肿瘤切除前全组患者腹腔冲洗液脱落癌细胞阳性表达56例。肿瘤切除后第1次腹腔冲洗液脱落癌细胞阳性64例,第2次阳性42例,第3次阳性3例。肿瘤切除前冲洗液脱落癌细胞阳性与术后第1次比较随检测例数有增加但无明显统计学意义,肿瘤切除后第1次冲洗液的脱落癌细胞阳性结果与切除后第2次冲洗液阳性结果比较差异无统计学意义。但第3次冲洗液的脱落癌细胞阳性结果与第1次比较,差异有统计学意义。结论对胃癌患者进行术中多次腹腔冲洗可降低腹腔内脱落癌细胞的阳性率。Objective To study the significance of repeated washing in reducing the positive rate of intra - abdominal exfoliated cancer cells. Methods Sequential intraoperative peritoneal lavages were performed in each of the 160 patients with gastric cancer one time before tumor resection, three times after excision. Four sub - peritoneal washing fluid was assayed for cytology smears with routine pathology. The results were then compared. Results Exfoliated tumor cells were positive in the intraoperative peritoneal lavages of 56 patients before resention. Exfoliated tumor cells were positive in the first three intraoperative peritoneal lavages of 64 patients before resention, 42 at the second,3 at the third. Tumor cells positive and forward setting lotion shed after the first time, with the number of detected cases increased but had no significant statistical significance. Compaving the positive result of the 3rd exfoliated cancer cells with the first 1 ,we found that the difference was statistically significant. Conclusion Sequential intraoperative peritoneal lavages is an useful method in reducing the positive rate of peritoneal exfoliated tumor cells in patients with gastric cancer.

关 键 词：胃癌 腹腔灌洗 脱落癌细胞 

分 类 号：R735.2[医药卫生—肿瘤]