原发扁桃体非霍奇金淋巴瘤的临床特征及预后分析  

Clinical characteristics and prognosis of primary non-Hodgkin's lymphoma of tonsil

作　　者：励菁菁[1] 朱琦[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院血液科,上海200011

出　　处：《诊断学理论与实践》2010年第2期170-172,共3页Journal of Diagnostics Concepts & Practice

摘　　要：目的:对原发扁桃体非霍奇金淋巴瘤的临床特点和预后进行分析,探讨临床指标与预后的关系。方法:回顾性分析49例原发扁桃体非霍奇金淋巴瘤患者的临床资料。结果:根据Ann Arbor分期,Ⅰa期为22例(44.90%),Ⅰb期为6例(12.24%),Ⅱa期为14例(28.57%),Ⅱb期为2例(4.08%),Ⅲa期为3例(6.12%),Ⅲb期为1例(2.04%),Ⅳa期为1例(2.04%)。病理类型,B细胞来源40例,占81.63%,T细胞来源9例,占18.37%。全组病例1、3、5年生存率分别为91.84%、81.63%、73.47%。临床资料单因素分析显示,B症状、肿瘤数目、首次治疗疗效、国际预后指数(IPI)均为原发扁桃体非霍奇金淋巴瘤患者生存期的预后影响因素(P<0.05)。多因素分析提示,IPI是原发扁桃体非霍奇金淋巴瘤患者生存期的独立预后影响因素。结论:原发扁桃体非霍奇金淋巴瘤预后较好,IPI是重要的独立预后影响因素。Objective To investigate the clinical characteristics and prognostic factors of primary non-Hodgkin＇s lymphoma of tonsil. Methods Forty-nine patients with primary non-Hodgkin＇s lymphoma of tonsil were analyzed retrospectively. Clinical data,treatment results and prognostic factors were investigated. Results According to the Ann Arbor staging system,44.90% patients had stage Ⅰa,12.24% stage Ⅰb,28.57% stage Ⅱa,4.08% stage Ⅱb,6.12% stage Ⅲa,2.04% stage Ⅲb and 2.04% stage Ⅳa. B cell origin was 81.63%,and T cell origin was 18.37%. The overall 1-,3- and 5-year survival rates were 91.84%,81.63% and 73.47%,respectively. Univariate analysis showed that B cell origin,number of tumor,response to initial treatment and international prognosis index （IPI） were the prognosis related factors of primary non-Hodgkin＇s lymphoma of tonsil （P〈0.05）. Multivariate analysis showed that IPI was the independent prognostic factor of primary non-Hodgkin＇s lymphoma of tonsil. Conclusions The prognosis of primary non-Hodgkin＇s lymphoma of tonsil is quite good,and IPI is the important and independent prognostic factor.

关 键 词：非霍奇金淋巴瘤 扁桃体 预后 分析 

分 类 号：R733.1[医药卫生—肿瘤]