平江白术多糖对腺嘌呤致大鼠肾衰模型的保护作用  

Protective Effect of Atractylodes rhizom Polysaccharides on Adenine-induced Renal Failure in Rats

作　　者：冯星[1] 邱细敏[1] 黄亚林[1] 刘雄志[1] 黎赛[1] 郑妮[2] 

机构地区：[1]湖南师范大学医学院,湖南长沙410006 [2]南方医科大学珠江医院,广东广州510515

出　　处：《食品科学》2010年第9期276-278,共3页Food Science

基　　金：湖南省自然科学基金项目(08JJ3024)

摘　　要：目的:探讨白术多糖对腺嘌呤诱发的慢性肾功能衰竭大鼠肾脏的保护作用。方法:采用腺嘌呤灌胃复制大鼠慢性肾衰模型,将大鼠随机分为正常对照组、模型对照组、地塞米松组、白术多糖高剂量组、白术多糖低剂量组。给药结束后,代谢笼动物单独喂饲,收集12h尿液,期间禁食禁水,测定总尿量、尿素(BUN)、尿肌酐(CR)、12h尿蛋白(24hU-TP)含量,并测定肾功能指标。结果:与模型对照组比较,白术多糖低剂量组和白术多糖高剂量组BUN水平明显降低(P<0.01或P<0.05),双肾系数明显下降(P<0.01或P<0.05)。结论:白术多糖对腺嘌呤诱发的慢性肾功能衰竭的大鼠肾脏具有一定的保护作用。Objective：To investigate the preventive effect of Atractylodes rhizome polysaccharides（AP） on chronic renal failure（CRF） rats-induced by adenine.Methods：CRF model was induced by adenine.The rats were randomized into five groups,which were designated as control group,model group,groups administered with AP at the high（APH） and low dosages（APL）,and dexamethasone group.After the administration,the rats were fed in metabolism cage.The urine was collected during 12 h period without food or water.The total volume of urine,blood urine nitrogen（BUN）,urine creatinine（CR）,and 12-hour urine protein（12 h U-TP） were determined.Meanwhile,renal index was also evaluated.Results：Compared with the model group,BUN levels of CPL and CPH groups exhibited a significant decrease（P0.01 or P0.05）.Similarly,a significant declined coefficient was also observed（P 0.01,P 0.05）.Conclusion：AP revealed a promising preventive effect on renal failure in rats.

关 键 词：白术多糖 腺嘌呤 大鼠 慢性肾衰 尿素 肾脏系数 

分 类 号：R965.1[医药卫生—药理学]