卡马西平和奥卡西平单药治疗儿童额叶癫的对照研究  

Case Control-Study on Efficacy of Carbamazepine and Oxcarbazepine in Treating Frontal Lobe Epilepsy as Monotherapy in Children

作　　者：黄铁栓[1] 朱金兰[1] 李冰[1] 廖建湘[1] 

机构地区：[1]深圳市儿童医院神经内科广东,深圳518026

出　　处：《实用儿科临床杂志》2010年第10期751-752,755,共3页Journal of Applied Clinical Pediatrics

摘　　要：目的比较卡马西平和奥卡西平单药治疗儿童额叶癫的疗效。方法收集本院新诊断的额叶癫47例儿童。男29例,女18例;年龄3～12岁;发作频率17～40次.d-1。根据就诊顺序按单双号顺序分成2组:卡马西平组和奥卡西平组,分别给予卡马西平和奥卡西平单药治疗。奥卡西平起始剂量8 mg.kg-1.d-1,每周增加5 mg.kg-1,逐渐加量至15～30 mg.kg-1.d-1,最大剂量40 mg.kg-1.d-1;卡马西平起始剂量5 mg.kg-1.d-1,每周增加5 mg.kg-1,逐渐增加剂量至10～20 mg.kg-1.d-1或其血药质量浓度达6～10 mg.L-1。随访6个月后评价2组疗效及不良反应。采用SPSS10.0软件进行统计学分析。结果共45例完成观察和随访,卡马西平组22例,奥卡西平组23例。卡马西平组13例完全控制发作(59.1%),3例部分控制(13.6%),其中3例随访6个月时EEG检查正常。奥卡西平组9例控制发作(39.1%),4例部分控制(17.4%),其中5例随访6个月时EEG正常。二组完全控制率、总有效率及EEG的改善比较均无统计学差异(Pa>0.05)。结论奥卡西平和卡马西平单药治疗儿童额叶癫均有很好疗效和耐受性。Objective To compare the efficacy of carbamazepine and oxcarbazepine in children with frontal lobe epilepsy as monotherapy.Methods Forty-seven children（29 male,18 female;3-12 years old） with childhood frontal lobe epilepsy were enrolled and evaluated.They had 17-40 seizures once a day.Eligible patients were divided into 2 groups,and the patients were treated with carbamazepine in CBZ group or oxcarbazepine in OXC group.The initial dosage of OXC was 8 mg·kg^-1·d^-1nd gradually increased every week（5 mg·kg-1） and maintenance dosage was 15-30 mg·kg^-1·d^-1he maximum dosage was 40 mg·kg^-1·d^-1he initial dosage of CBZ was 5 mg·kg^-1·d^-1nd was weekly increased by 5 mg·kg-1 weekly until the dosage amounted to 10-20 mg·kg^-1·d^-1r a plasma concentration of 6-10 mg·L^-1.All patients had at least been followed up 6 months.SPSS 10.0 software was used to analyze the data.Results Forty-five children completed the study,23 children took OXC,and 22 children took CBZ.Thirteen children were seizure-free（59.1%）,3 cases were partially controlled（13.6%） in CBZ group,and 3 cases of them showed normal electroencephalography（EEG） at the end of the 6 months;In the OXC group,9 children were seizure-free（39.1%）,4 cases were partially controlled（17.4%）,and 5 cases of them showed normal EEG at the end of the 6 months.Severe adcerse effects were not found in all patients（Pa〉0.05）.Conclusions Both CBZ and OXC are effecive in treating typical frontal lobe seizures.

关 键 词：卡马西平 奥卡西平 额叶癫 儿童 

分 类 号：R742.1[医药卫生—神经病学与精神病学]