脾窦岸细胞血管瘤3例临床病理分析  

Splenic littoral cell angioma:a clinicopathologic analysis of three cases

作　　者：杜军[1] 吴波[1] 金行藻[1] 周航波[1] 石群立[1] 周晓军[1] 

机构地区：[1]南京大学医学院临床学院南京军区南京总医院病理科,南京210002

出　　处：《诊断病理学杂志》2010年第2期107-110,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨脾窦岸细胞血管瘤(LCA)的临床病理特征、诊断与鉴别诊断要点。方法对3例脾窦岸细胞血管瘤进行常规病理检查、组织化学染色、免疫组化标记及电镜观察,并复习临床资料和相关文献。结果3例LCA患者均为中老年男性,组织学上肿瘤由大小不等的、互相吻合的血管性腔隙组成,腔隙被覆低柱状或立方形内皮细胞,无明显异型性。免疫表型:肿瘤细胞CD31、CD8、CD68、Ⅷ因子和lysozyme(+),CD34和D2-40(-)。结论LCA是很少见的、仅发生在脾的血管肿瘤,CT和B超检查可以发现病变,确诊还需依靠病理学及免疫组化检查。该肿瘤常伴有其他内脏疾病。Objective To study the clinicopathological changes of splenic littoral cell angioma and the key points of its diagnosis and differential diagnosis. Methods Routine paraffin section techniques, HE stain, and microscopic examination were performed on the three cases of surgical specimens, meanwhile, the tumor tissues were studied immunohistochemically staining with CD31, CD34, CD8, CD68, Factor Ⅷ, lysozyme, and D2-40. Simultaneously electron microscopy was performed with review of the literature. Results The three patients were middle aged or old. Microscopicaly, all of the three cases showed typical hallmarks of littoral cell angiomas with large sinus-like anastomosing channels lined by tall and plump cells, without nuclear atypia or increased mitotic activity. Immunohistochemically, the tumor cells were positive for Factor Ⅷ, CD31, CD8, CD68 and lysozyme, but negative for CD34 and D2-40. Conclusions Littoral cell angioma is an extremely rare primary vascular tumor of the spleen, which is usually CT and US findings. But its diagnosis is based on the microscopic and immunohistochemical features. The tumor is often accompanied by other visceral diseases.

关 键 词：脾肿瘤 窦岸细胞血管瘤 免疫组化 

分 类 号：R733.2[医药卫生—肿瘤]