电损毁前扣带回皮质对晕动病的影响(英文)  

Effect of electrolysis of anterior cingulate cortex on motion sickness

作　　者：刘立鹏[1] 董加强[1] 张卓超[1] 刘国才[1] 张富兴[2] 李金莲[2] 李云庆[2] 

机构地区：[1]第四军医大学2006年级学员,西安710032 [2]第四军医大学人体解剖与组织胚胎学教研室暨梁鲸琚脑研究中心,西安710032

出　　处：《神经解剖学杂志》2010年第1期15-19,共5页Chinese Journal of Neuroanatomy

基　　金：国家自然科学基金(30470562)~~

摘　　要：目的:通过对大鼠异食癖程度的观察来判断前庭皮质中前扣带回皮质(ACC)是否在(动病(MS)的产生中起到作用。方法:两组大鼠(对照组和ACC损毁组)接受2h双轴旋转刺激。结果:对照组在高岭土的摄食上产生了很大的差异(P<0.05),而ACC损毁组的摄取量却没有发生改变(P>0.05).后数据经Two-WayANOVA处理后显示同对照组比较,手术组的高岭土摄食量在旋转刺激后减少(P<0.05)。结论:结合组织学证明损毁部位局限于ACC部位这一形态学依据,本研究结果提示ACC在正常神经网络通过参与前庭信息的处理,在MS发生上起到了重要的作用。Objective：The present work aims to examine whether the vestibular-cortex,anterior cingulate cortex（ACC）,plays a role in development of motion sickness（MS）in rat.Methods：Picaism is a symptom indicating motion sickness in rat which didn＇t have emesis response.Two groups of rats received a 2-hour double rotation exposure,with the experimental group being lesioned by electrolysis at ACC.Results：We observed that rotation stimulation induced a significant increase in kaolin intake in control group（P 0.05）,but not in experimental group（P 0.05）.Data which had analyzed by two-way ANOVA indicated that lesion of ACC caused significant decrease in kaolin consumption post-rotation（P〈0.05）with comparison of control group.Conclusion：Taken together with the histological results indicating that the electrolysis was restricted to ACC,the present data suggest that ACC,through vestibular information processing by its neurons,exerts a facilitatory role in development of MS.

关 键 词：晕动病 前扣带回皮质 异食癖 高岭土 电损毁 

分 类 号：R594.6[医药卫生—内科学]