Comparable rate of EGFR kinase domain mutation in lung adenocarcinomas from Chinese male and female never-smokers  

作　　者：Yi-hua SUN Rong FANG Bin GAO Xiang-kun HAN Jun-hua ZHANG William PAO Hai-quan CHEN Hong-bin JI 

机构地区：[1]Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China [2]Thoracic Surgery, Shanghai Cancer Hospital, Fudan University, Shanghai 200032, China [3]Vanderbilt-lngram Cancer Center, 2220 Pierce Avenue, 777 Preston Research Building, Nashville, TN 37232-6307, USA

出　　处：《Acta Pharmacologica Sinica》2010年第5期647-648,共2页中国药理学报（英文版）

基　　金：Acknowledgements This work was supported by the National Basic Research Program of China （No 2010CB912102）, the National Natural Science Foundation of China （No 30623003, 30740084, and 30871284）, the Chinese Academy of Sciences （No 2008KIP101, KSCX1-YW-22）, the Science and Technology Commission of Shanghai Municipality （No 08PJ14105, 09JC1416300） and the Hundred Talents Program of the Chinese Academy of Sciences to Prof Hong-bin JI.

摘　　要：Lung cancer patients with the epidermal growth factor receptor （EGFR） kinase domain mutations frequently show good responses to small molecule tyrosine kinase inhibitors, including Iressa and Tarceva, in clinical studies. Previous studies have demonstrated that EGFR kinase domain mutations are commonly observed in lung East Asian, and females. adenocarcinomas, never-smokers, In contrast to caucasion females, most East Asian females do not smoke, while tobacco smoking is very common in the male population. This gender-associated tobacco usage may bias the EGFR mutation incidence in lung adenocarcinoma patients. Here we analyzed the EGFR mutation rate together with gender and smoking status in Chinese lung adenocarcinoma patients. Interestingly, our results showed a comparable rate of EGFR kinase domain mutations in lung adenocarcinomas from Chinese male and female never-smokers.Lung cancer patients with the epidermal growth factor receptor （EGFR） kinase domain mutations frequently show good responses to small molecule tyrosine kinase inhibitors, including Iressa and Tarceva, in clinical studies. Previous studies have demonstrated that EGFR kinase domain mutations are commonly observed in lung East Asian, and females. adenocarcinomas, never-smokers, In contrast to caucasion females, most East Asian females do not smoke, while tobacco smoking is very common in the male population. This gender-associated tobacco usage may bias the EGFR mutation incidence in lung adenocarcinoma patients. Here we analyzed the EGFR mutation rate together with gender and smoking status in Chinese lung adenocarcinoma patients. Interestingly, our results showed a comparable rate of EGFR kinase domain mutations in lung adenocarcinomas from Chinese male and female never-smokers.

分 类 号：R[医药卫生]