辛伐他汀对大鼠胫骨骨缺损修复作用的实验研究  

Experimental study on bone formation in defect of ratstibia by Simvastatin be taken orally

作　　者：刘志强 周磊[2] 邹剑曾 李东健 司徒燕 王继洲 

机构地区：[1]广州市荔湾区口腔医院,广东广州510170 [2]广东省口腔医院.南方医科大学附属口腔医院

出　　处：《临床口腔医学杂志》2010年第4期214-217,共4页Journal of Clinical Stomatology

基　　金：广东省自然科学基金项目(32569)

摘　　要：目的:研究辛伐他汀作为激活物对骨生成的促进作用。方法:通过制备大鼠胫骨骨缺损模型填入Bio-oss骨粉,同时给予口服辛伐他汀(实验组),并设立空白组、对照组(骨缺损单纯填入Bio-oss骨粉),于术后4、8、12周分别处死大鼠,进行定性、定量分析,观测骨增量变化。结果:空白组无法形成正常骨愈合;实验组在骨量形成和新骨改建速度方面明显优于对照组。结论:辛伐他汀有促进新骨生成作用。Objective：To study stimulation of bone formation by statins（simvastatin）as a activation.Method：72 SD rats（3mm defect of left tibia）were random treated with three groups：1.untreated group;2.comparison group：Bio-oss alone be filled in defect of tibia;3.experiment group：compounding simvastatin be taken orally.The rats were sacrificed in 4、8 and 12 weeks and the bone formation was observed.Result：The difference was obvious in 8 and 12 weeks.Compared group 2 and 3,the bone formation of group 3 was better in quality and velocity.Conclusion：Simvastatin as a activation can improve bone formation in defect of rats tibia.

关 键 词：辛伐他汀 骨缺损 成骨作用 

分 类 号：R782.2[医药卫生—口腔医学]