吸烟对脑血栓患者血浆组织因子水平的影响  

Effect of Cigarette Smoking on the Level of Plasma Tissue Factor in Brain Ischemic Patients

作　　者：吴戈[1] 徐爱华[2] 万功山[3] 

机构地区：[1]沈阳市第五人民医院神经内科,辽宁省沈阳市110023 [2]中国医科大学附属第一医院康复科,辽宁省沈阳市110001 [3]沈阳市第八人民医院,辽宁省沈阳市110024

出　　处：《中国动脉硬化杂志》2010年第2期151-153,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的观察吸烟脑血栓患者及吸烟健康者血浆组织因子水平的变化,探讨吸烟对脑血栓形成的影响。方法采用双抗体夹心酶联免疫吸附法测定45例吸烟脑血栓患者和43例不吸烟脑血栓患者及42例吸烟健康者和45例不吸烟健康者血浆组织因子水平。结果吸烟脑血栓患者血浆组织因子水平明显高于不吸烟脑血栓患者和不吸烟健康者(P<0.01);吸烟健康者血浆组织因子水平明显高于不吸烟健康者(P<0.01)。重度吸烟者血浆组织因子水平明显高于中度吸烟者、轻度吸烟者及不吸烟健康者(P<0.05或0.01)。吸烟指数与血浆组织因子水平呈正相关(r=0.43,P<0.01)。结论长期吸烟致血浆组织因子水平升高可能在脑血栓形成中发挥重要作用。Aim To investigate the change of plasma tissue factor（TF） level in the ischemic smoker and the healthy smoker,and discuss the influence of cigarette smoking on cerebral thrombosis.Methods Plasma TF levels of 45 smoking brain ischemic patients,43 non-smoking brain ischemic patients,42 healthy smokers and 45 healthy non-smokers were detected with two-layer antibody sandwich enzyme-linked immunosorbent assay（LWISA）.Results The plasma TF level of smoking brain ischemic group was obviously higher than that of non-smoking brain ischemic group（P0.01） and healthy non-smoking group（P0.01）;TF level of healthy smoking group was obviously higher than that of non-smoking healthy group（P0.01）,and heavy smoking group was obviously higher than middle smoking group（P0.05）,little smoking group（P0.01）and healthy group（P0.01）.The smoking index was positively correlated with the plasma TF value（r=0.43,P0.01）.Conclusion The improvement of plasma TF level induced by smoking may be a pathway through which smoking induce brain atherosclerosis and cerebral thrombosis.

关 键 词：吸烟 脑血栓形成 组织因子 酶联免疫吸附法 

分 类 号：R741[医药卫生—神经病学与精神病学]