对比剂剂量及注射流率对去卷积法兔肝脏CT灌注值的影响  

Influence of various doses and injection rates of contrast agent on CT perfusion in rabbits' liver with deconvolution method

作　　者：肖景坤[1,2] 刘斌[1] 王万勤[1] 方雷[1] 吴兴旺[1] 余永强[1] 

机构地区：[1]安徽医科大学第一附属医院放射科,安徽合肥230022 [2]安徽省立医院影像科,安徽合肥230002

出　　处：《中国医学影像技术》2010年第4期612-615,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨去卷积法肝脏CT灌注成像时对比剂剂量和注射流率对灌注参数值的影响。方法对8只实验兔采用配伍组设计:处理因素为注射流率,分别为0.5ml/s、1.0ml/s、1.5ml/s;配伍因素为对比剂剂量,分别为0.5ml/kg、1.0ml/kg、1.5ml/kg。将灌注扫描数据传入工作站,利用Perfusion3中的肝脏灌注软件进行分析,计算各灌注值。结果对比剂剂量对主动脉、门静脉和肝实质增强峰值有显著性影响(P<0.05);对比剂注射流率对主动脉、门静脉的增强峰值时间有显著性影响(P<0.05);注射流率和剂量对肝血流量(HBF)、肝动脉指数(HAF)、肝血容量(HBV)、毛细血管平均通过时间(MTT)和表面通透性(PS)均无显著性影响(P>0.05)。结论去卷积法肝脏CT灌注成像可以定量研究肝脏微循环血流动力学状态,结果稳定,对对比剂剂量和注射流率要求相对不高,有较好的临床实用价值。Objective To study the influence of various doses and injection rates of contrast agent on CT perfusion in rabbits＇ liver with a deconvolution mathematical model. Methods Eight rabbits were enrolled in the experiment. Randomized block design was adopted. The treatment factor （contrast medium injection rate） was classified into 0.5,1.0,1.5 ml/s,while the subjects were divided into 3 blocks with contrast medium injection dose of 0.5,1.0 and 1.5 ml/kg. The data obtained at CT perfusion imaging were then transferred to the workstation. Absolute values of 7 perfusion parameters （hepatic arterior fraction,blood flow,blood volume,permeability surface,mean transmit time,hepatic artery perfusion and portal vein perfusion） were measured with perfusion software （Perfusion 3）. Results The dose of contrast medium had significant effect on peak enhancement of the aorta,the portal vein and liver tissue （P〈0.05）,whereas the injection rates had significant influence on the arrival time to peak enhancement of the aorta and the portal vein. However,the dose of contrast medium and injection rates had no significant effect on perfusion parameters （P〉0.05）. Conclusion CT perfusion imaging with a deconvolution mathematical model can quantify the hemodynamic functional status in liver with stable results. This technique does not need strict confinement to dose and injection rate of contrast medium,and has great potential value to be put into clinical use.

关 键 词：肝脏 体层摄影术 X线计算机 灌注成像 对比剂 

分 类 号：R-332[医药卫生] R814.42