非小细胞肺癌组织中Survivin和环氧合酶2的表达及其临床意义  

Expression and clinical significance of Survivin and cyclooxygenase-2 in non-small cell lung cancer tissues

作　　者：易征[1] 张美平[2] 

机构地区：[1]湖南省浏阳市人民医院胸外科,410300 [2]湖南省浏阳市人民医院病理科,410300

出　　处：《中国医师进修杂志》2010年第15期19-21,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的 探讨Survivin和环氧合酶2（COX-2）在非小细胞肺癌组织中的表达及与组织分化程度、淋巴结转移和临床分期的关系.方法 应用免疫组化SP染色法检测Survivin、COX-2在非小细胞肺癌组织（肺癌组,43例）和癌旁正常肺组织（对照组,20例）中的表达情况.结果 Survivin和COX-2在肺癌组中的阳性表达率分别为67.4%（29/43）和55.8%（24/43）;在对照组中均无表达;Survivin和COX-2在两组中的表达差异有统计学意义（P〈0.01）. Survivin和COX-2在有淋巴结转移、临床分期为Ⅱ～Ⅲ期及低分化的非小细胞肺癌组织中阳性表达率显著高于无淋巴结转移、临床分期为Ⅰ期及高、中分化的非小细胞肺癌组织（P〈0.05）. 结论 Survivin和COX-2在非小细胞肺癌组织中均有高表达,且与组织分化程度、淋巴结转移和临床分期密切相关.Objective To study relationship of expression of Survivin and cyclooxygenase（COX）-2 in the tissue of non-small cell lung cancer （NSCLC） with differentiation, lymph node metastasis and clinical stage. Method The expression of Survivin and COX-2 were detected by immunohistochemical SP staining in the specimens of 43 cases of NSCLC and 20 cases of para-cancerous lung tissue. Results The positive rate of Survivin and COX-2 was 67.4% （29/43） and 55.8% （24/43） respectively in NSCLC,was 0 respectively in the para-cancerous lung tissue. Compared with para-cancerous lung tissue,there was statistically significant difference（P〈 0.01）. Both Survivin and COX-2 had significantly higher expression in NSCLC with poor differentiation,lymph node metastasis and clinical stage of Ⅱ-Ⅲ than those with well differentiation,without metastasis and clinical stage of Ⅰ （P 〈0.05）. Conclusion The expression of Survivin and COX-2 are high in NSCLC,they both have relationship with differentiation,lymph node metastasis and clinical stage of NSCLC.

关 键 词：癌 非小细胞肺 基因表达 环氧化酶2 SURVIVIN 

分 类 号：R734.2[医药卫生—肿瘤]