骨桥蛋白、CD44v6在涎腺腺样囊性癌转移中的意义  

The role of osteopontin and CD44v6 in metastasis of salivary gland adenoid cystic carcinoma

作　　者：陈垂史 黄志权[2] 王友元[2] 张大明[2] 赵小朋[2] 王慧菁[2] 李海刚[3] 

机构地区：[1]广东省深圳龙岗区中心医院口腔科,广东深圳518116 [2]中山大学孙逸仙纪念医院口腔颌面外科,广东广州510120 [3]中山大学孙逸仙纪念医院病理科,广东广州510120

出　　处：《分子诊断与治疗杂志》2010年第3期160-163,共4页Journal of Molecular Diagnostics and Therapy

基　　金：广东省医学科研基金(B2008036)

摘　　要：目的探讨骨桥蛋白(osteopontin,OPN)、细胞黏附分子CD44v6在涎腺腺样囊性癌(adenoid cystic carcinoma,ACC)组织中的表达及与肿瘤远处转移的关系。方法采用免疫组织化学SP法检测48例ACC组织及18例正常涎腺组织中OPN、CD44v6的表达。结果 OPN在ACC和正常涎腺组织中的阳性表达率分别为79.17%(38/48)、16.67%(3/18);CD44v6的阳性表达率分别为75.00%(36/48)、11.11%(2/18),OPN、CD44v6在ACC与在正常涎腺组织中的阳性表达率比较差异均具有统计学意义(P<0.01)。OPN、CD44v6在有远处转移的ACC中阳性表达率分别为94.44%(17/18)、94.44%(17/18),在无远处转移的ACC组织中阳性表达率分别为70.00%(21/30)、63.33%(19/30),OPN和CD44v6的阳性表达均与肿瘤有无远处转移有关(P<0.05)。在ACC组织中OPN与CD44v6之间的表达呈正相关(P<0.05)。结论 OPN和CD44v6可能在ACC的发生、发展中起一定作用,联合检测OPN、CD44v6可作为预测ACC患者远处转移的分子诊断标志物之一。Objective To study the expression of osteopontin（OPN） and CD44v6 in adenoid cystic carcinoma（ACC） and the relationship between the positive rate of OPN,CD44v6 and ACC metastasis.Methods The expressions of OPN,CD44v6 in 48 cases of ACC tissue and 18 cases of normal salivary gland tissue were detected by immunohistochemistry SP method.Results The positive expression rate of OPN in ACC and normal tissues was 79.17%（38/48） and 16.67%（3/18）,respectively,while CD44v6 expression rate was 75.00%（36/48） and 11.11%（2/18）,respectively.The expression rates of OPN and CD44v6 were different statistically between ACC and normal tissues（P0.01）.The positive expression rate of OPN,CD44v6 in ACC with metastasis was 94.44%（17/18）,94.44%（17/18）,respectively,and that without metastasis was 70.00%（21/30）,63.33%（19/30）.The expression rates of OPN and CD44v6 were different statistically between ACC with and without metastasis（P0.05）.There was a significant correlation between expression of OPN and CD44v6 in ACC（P0.05）.Conclusion Expression of OPN,CD44v6 may play a role in ACC tumorigenesis and development.Detection of OPN and CD44v6 can be one of the molecular diagnostic markers to prognosis of ACC metastasis.

关 键 词：腺样囊性癌 骨桥蛋白 细胞黏附分子CD44v6 免疫组织化学 

分 类 号：R739.8[医药卫生—肿瘤]