鼻咽癌^(18)F-FDG PET/CT表现和血清EBV-VCA/IgA相关性的研究  

The study on the relationship between nasopharyngeal carcinoma ^(18)F-FDG PET/CT findings and serum EBV-VCA/IgA titer levels

作　　者：孙新儒[1,2] 梁培炎[1,2] 胡莹莹[1,2] 张旭[1,2] 林晓平[1,2] 樊卫[1,2] 

机构地区：[1]华南肿瘤学国家重点实验室,广东广州510060 [2]中山大学肿瘤防治中心核医学科,广东广州510060

出　　处：《分子诊断与治疗杂志》2010年第3期176-180,共5页Journal of Molecular Diagnostics and Therapy

摘　　要：目的本文旨在探讨鼻咽癌患者18F-FDG PET/CT表现和血清EBV-VCA/IgA滴度水平是否具有相关性,以期能进一步指导临床工作。方法收集113例鼻咽癌初诊患者首次放疗前的PET/CT资料,及同期采用免疫酶法测定的外周静脉血清EB病毒VCA/IgA结果。分析入选患者原发灶SUV值、原发灶大小、颈部淋巴结转移情况及远处转移和血清EBV-VCA/IgA抗体滴度水平之间的关系。结果 113例患者中,Ⅰ期2例,Ⅱ期13例,Ⅲ期61例,Ⅳa期24例,Ⅳb期13例。Spearman秩和相关结果显示:SUVmax、SUVmean与血清EBV-VCA/IgA之间的相关系数rs分别为0.009和0.015,P>0.05。鼻咽癌颈部淋巴结转移情况和EBV-VCA/IgA抗体滴度水平具有相关性,N0~N3期之间的差异具有统计学意义(P=0.035<0.05)。据病灶大小和远处转移与否分组,血清EBV-VCA/IgA在各组的差异无统计学意义(P>0.05)。结论鼻咽癌18F-FDG PET/CT确定的颈部淋巴结转移情况和血清EBV-VCA/IgA抗体滴度水平之间存在相关,并且N0~N3期VCA/IgA抗体滴度水平逐渐升高;原发灶SUV值、原发灶大小及远处转移与EBV-VCA/IgA抗体滴度水平无明显的关联性。Objective To investigate the relationship between 18F-FDG PET/CT findings and the serum EBV-VCA/IgA titer levels of nasopharyngeal carcinoma（NPC）.Methods In total 113 histologically diagnosed NPC patients without any radiotherapy underwent 18F-FDG PET/CT were entered into this retrospective study.The concurrent serum antibodies determination of EBV-IgA/VCA with immunoenzymic method were recorded in all 113 NPC patients.Analysis the relationship between primary tumor standardized uptake value（SUV）,tumor size,cervical lymph node metastasis and distant metastasis and serum EBV-VCA/IgA of selected patients.Results Among 113 patients：2 cases wereⅠstage,13 cases wereⅡstage,61 cases were Ⅲ stage,24 cases were Ⅳa stage,and 13 cases were Ⅳb stage.Spearman rank test results showed that：the correlation coefficient（rs） between SUVmax,SUVmean and serum EBV-VCA/IgA were 0.009 and 0.015,respectively.Cervical lymph node metastasis of NPC and EBV-VCA/IgA titer levels had correlation;the difference of N0~N3 stages had a statistical signi？cance（P=0.0350.05）.Patients were categorized according to lesion size and distant metastasis,and EBV-VCA/IgA titer levels were of no statistical signi？cance（P0.05） in every group.Conclusion NPC cervical lymph nody metastasis detected by 18F-FDG PET/CT and EBV-VCA/IgA titer levels exist relationship,and it step up gradually from N0 stage to N3 stage.The primary lesion SUV,focal size and distant metastasis occurrence had no relevance with EBV-VCA/IgA titer levels.

关 键 词：鼻咽肿瘤 体层摄影术 X线计算机 18F-氟脱氧葡萄糖 PET/CT EB病毒 血清抗体 

分 类 号：R739.63[医药卫生—肿瘤]