大肠癌患者手术前后血清可溶性细胞间粘附分子-1和血管内皮生长因子检测的临床意义  

Clinical significance of sICAM-1 and VEGF levels before and after operation in patients with colorectal carcinoma

作　　者：李俊江[1] 高凌[1] 

机构地区：[1]河南省商丘市第一人民医院普外一科,476100

出　　处：《中国综合临床》2010年第4期361-363,共3页Clinical Medicine of China

摘　　要：目的 观察大肠癌患者手术治疗前后可溶性细胞间粘附分子-1（sICAM-1）和血管内皮生长因子（VEGF）水平的变化,分析与大肠癌临床病理因素的关系.方法 采用双抗体夹心法测定35例大肠癌患者手术前后血清sICAM-1和VEGF,并与35名健康成年人（对照组）作比较.结果 大肠癌患者手术前血清sICAM-1和VEGF分别为（230.78±61.22）μg/L和（310.15±51.56）ng/L,明显高于对照组的（151.22±51.61）μg/L和（137.33±60.21）ng/L（P均〈0.01）;且C期[（238.83±60.17）μg/L和（330.15±50.13）ng/L]高于A＋B期[（216.78±53.11）μg/L和（301.11±49.06）ng/L],淋巴结转移组[（251.01±59.27）μg/L和（318.78±52.33）ng/L]高于无淋巴结转移组[（220.13±63.19）μg/L和（293.66±41.98）ng/L]（P均〈0.05）;手术后6个月复发组与未复发组血清sICAM-1和VEGF分别为（220.16 4±54.46）μg/L和（307.11±47.88）ng/L对（173.06±60.13）μg/L和（146.28±51.26）ng/L（P均〈0.05）;复发者血清sICAM-1和VEGF水平持续异常,未复发者血清sICAI-1和VEGF水平恢复正常.结论 大肠癌患者血清中sICAM-1和VEGF的水平与大肠癌的Dukes分期和淋巴结转移有关,其水平的变化反映术后有否复发,可作为判断肿瘤发展程度、转移状况以及预后的指标之一.Objective To observe the changes of sICAM-1 and VEGF levels after operation in patients with colorectal carcinoma,and analyze the relationship between the sICAM-1,VEGF levels and clinical pathological factors.Methods The sICAIM-1 and VEGF levels were measured with ELISA in 35 patients with colorectal carcinoma both before and after operation as well as in 35 controls of healthy adults.Results Before operadon,the serum sICAM-1 and VEGF levels in the patients [（230.78±61.22）μg/L and （310.15±51.56）ng/L,respectively]were significantly higher than those in the controls [（151.22±51.61）μg/L and （137.33±60.21）ng/L] （P〈O.01）,and were much higher in stage C [（238.83±60.17）μg/L and （330.15±50.13）ng/L] than that in stage A and B [（216.78±53.11）μg/L and （301.11±49.06）.ng/L] （P〈0.05）.There were also significant difference between colorectal carcinomas with [（251.01±59.27）μg/L and （318.78±52.33）ng/L] and without lymph node metastasis [（220.13±63.19）μg/L and（293.66±41.98）ng/L]（p〈0.05）.Six months after operation,the two indexes were（173.06±60.13）μg/L and （146.28±51.26）ng/L in patients without recurrence,which returned to normal level,and （220.16±54.46）μg/L and（307.11±47.88）ng/L in the patients with recurrence the levels,which were similar to those before operation.Conclusions The levels of serum sICAM-1 and VEGF in patients with colorectal carcinoma were closely related to the Dukes stages and lymph node metastasis.It might be indices to predict tumor development,metastasis and prognosis.

关 键 词：大肠癌 可溶性细胞间粘附分子-1 血管内皮生长因子 预后 

分 类 号：R735.34[医药卫生—肿瘤]