三叉神经痛慢性缩窄环术大鼠动物模型建立的研究  

Establishment of rat animal model for trigeminal neuralgia following chronic constriction injury

作　　者：王延秀[1] 

机构地区：[1]泰山医学院附属泰安医院麻醉科,山东泰安271000

出　　处：《泰山医学院学报》2010年第4期248-251,共4页Journal of Taishan Medical College

基　　金：泰安市科技局资助项目(NO.2003-52)

摘　　要：目的 探讨建立三叉神经痛慢性缩窄环术大鼠动物模型的效果.方法 将大鼠随机分为手术组及假手术组,手术组用两根铬线疏松环扎大鼠的眶下神经造成慢性缩窄损伤,而假手术组只暴露神经,但不结扎,观察术后不同时段大鼠对机械刺激的反应阈值（疼痛阈值）及相关的痛觉行为变化.结果 手术组术后2～8周,在眶下神经支配区域内,大鼠出现痛觉超敏现象,与手术对侧、术前及对照组比较存在显著差异（P〈0.01）,术后12周左右恢复至术前水平.结论 大鼠眶下神经的慢性环扎损伤可导致三叉神经痛出现,压迫解除后疼痛可缓解.Objective： To establish a rat animal model of trigeminal neuralgia for the basic research on the mechanism and therapy. Methods： Rats were randomly divided into two groups： the operation group and the sham operation group. In the operation group, an unilateral chronic constriction injury（CCI） was produced by placing loose chromic gut ligatures around the infraorbital nerve（ION）. In the sham operation group, the ION was only exposed using the same procedure but not ligated. The behavioral reactions and the mechanical response threshold （ pain threshold ） were observed at different times after operation. Results ： An allodynia to mechanical stimulation on the territory of ligated ION was found from the 2nd to the 8th week after operation in the operative group. There was significant difference （P 〈 0.01 ） in pain threshold, compared with the pre-operation and the contralateral side in the operation group and the sham-operation group. The thresholds started to increase gradually from the 4th week and reached the original level on 12th week after operation. Conclusion： CCI-ION results in experimental trigeminal neuralgia, which can be relieved by decompression.

关 键 词：三叉神经痛 动物模型 行为学反应 疼痛阈值 慢性缩窄环 大鼠 

分 类 号：R-332[医药卫生]