阻塞性睡眠呼吸暂停低通气综合征与短暂性脑缺血发作关系的病例对照研究  

Obstructive sleep apnea syndrome and transient ischemic attack:a case-control study

作　　者：许林生[1] 

机构地区：[1]揭阳市人民医院康复科,广东揭阳522000

出　　处：《临床和实验医学杂志》2010年第12期887-889,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与短暂性脑缺血发作(TIA)的关系。方法对86例TIA患者和性别、年龄相匹配的查体者按1:1配成,使用多导睡眠检测仪检测,同时进行TIA危险因素和OSAHS症状问卷,完成Epworth嗜睡量表(ESS),检测血压,体质量,身高,清晨空腹血糖,血纤维蛋白原。结果睡眠呼吸暂停低通气指数(AHI)在TIA组和对照组无显著性差异,血纤维蛋白原、高血压病史、高胆固醇血症、吸烟史、心肌梗死病史在TIA组中显著高于对照组。结论 OSAHS不是TIA的危险因素。Objective We explored the relationship of obstructive sleep apnea-hypopnea syndrome （OSAHS） and transient ischemic attack （TIA）.Methods We performed a case-control study in patients with TIA from our hospital,matched for age and sex with controls from the referring outpatients.All participants underwent full overnight polysomnography in the Sleep Centre and been measured with pressure,weight,sight,fasting blood glucose and serum fibrinogen.Daytime sleepiness was assessed using the Epworth sleepiness score （ESS）,a self-administered in-house questionnaire about vascular risk factors for TIA and symptoms of the OSAHS also been used.Results The primary outcome measure,the apnea-hypopnea index （AHI） was the same for cases and controls （21/hour）.However,the median number of 4% desaturations during sleep was slightly greater in the cases （12/hour） than control （6/hour,P=0.04）.There were significant associations between TIA and higher fibrinogen level,previous myocardial infarction,the history of ever smoking,hypertension and raised cholesterol.Conclusion OSAHS does not appear to be strongly associated with TIA.

关 键 词：短暂性 脑缺血发作 睡眠呼吸暂停低通气指数 

分 类 号：R743[医药卫生—神经病学与精神病学]