人脑对味觉刺激反应的功能磁共振成像的任务模式的初步探讨  

A Pilot Study on Task Pattern Exploring the Brain Cortex Activated by Taste with fMRI

作　　者：刘雪梅[1] 刘洪臣[1] 金真[1] 李科[2] 

机构地区：[1]解放军总医院口腔科,北京100853 [2]解放军306医院核磁共振室,北京100101

出　　处：《中国医药导刊》2010年第5期837-838,共2页Chinese Journal of Medicinal Guide

基　　金：国家自然科学基金项目(30772450);北京市自然科学基金项目(7082086)

摘　　要：目的:探讨运用功能性磁共振成像(fMRI)技术进行味觉的大脑皮层定位研究中,采用在同一次扫描中给予每个被试者两种不同味觉刺激的事件相关任务模式的可行性。方法:选取右利手健康志愿者1名,采用软管注射味觉刺激液体的装置及甜、咸和无味对照随机给予的事件相关任务模式,采集全脑fMR扫描数据,并用SPM2软件包进行结果的数据分析获得脑功能图像。结果:人脑对甜、成两种味觉刺激反应所产生的激活区不同,甜味觉激活的脑区较咸味觉更广泛。结论:本实验所采用的事件相关任务模式,可用于研究不同味觉与脑功能关系的对比研究,明确人脑对味觉刺激反应的激活区还有待于进一步实验结果。Objective： To evaluate the feasibility of exploring the brain cortex activated by taste with fMRI induced by event-relate designed stimulate task pattern. Methods：fMRI-BOLD scan covering the whole brain was performed on a healthy right-handed human subject during event- relate designed stimulation with sweet taste, salty taste and tasteless control.The fMRI data was analyzed by SPM99 software with statistic t-test to generate the activation map. Results：Cortical representation of sweet and salty taste was not similar, sweet taste activated more areas than salty one.Conclusions： The event- relate designed taste stimulate task pattern has proper feasibility exploring the brain cortex activation with fMRI. The exact brain regions for taste need to be elucidated by further study.

关 键 词：口腔功能 脑功能 味觉 功能磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]