XIAP在胰腺癌化疗耐药及治疗中的研究进展  

Research on X-linked Inhibitor of Apoptosis Protein in Chemoresistance and Treatment of Pancreatic Cancer

作　　者：严晓丹[1,2] 戴岭[1,2] 蒋敏[1,2] 宋旺盛[1,2] 刘俊[1] 

机构地区：[1]上海交通大学附属第一人民医院普外科,上海200080 [2]南京医科大学第一临床医学院,南京210029

出　　处：《现代生物医学进展》2010年第9期1768-1770,共3页Progress in Modern Biomedicine

摘　　要：X连锁的凋亡抑制蛋白(X-linked inhibitor of apoptosis protein,XIAP)是凋亡抑制蛋白家族中的一员,具有抗凋亡作用。研究发现XIAP在胰腺癌中呈高表达,并且能诱导胰腺癌细胞及组织对化疗耐药。通过在基因水平及蛋白水平降低XIAP的表达对胰腺癌的治疗具有重要意义。AEG35156是针对XIAP的反义寡核苷酸分子,能够抑制胰腺癌细胞及组织生长。RNAi能够稳定下调胰腺癌细胞中XIAP水平,从而加强TRAIL诱导的细胞凋亡,并能提高胰腺癌细胞对化疗的敏感性。针对XIAP的小分化合物能够抑制XIAP的功能,释放被XIAP抑制的凋亡起始和效应分子以及XIAP抑制的其他促凋亡蛋白,提高多种肿瘤细胞的凋亡指数及对放化疗的敏感性。XAF1能抑制XIAP的抗凋亡作用。本文就XIAP在胰腺癌化疗耐药及治疗中的研究进展做一综述。X-linded inhibitor of apoptosis protein（XIAP） is a member of the inhibitor of apoptosis proteins family which inhibits apoptosis.Previous researches revealed that XIAP was up-regulated in pancreatic cancer cells and tissues,with the ability of inducing chemoresistance.It makes sense to down-regulate XIAP either from gene level or protein level.AEG 35156 is an antisense oilgonucleotide tagarting XIAP which could inhibit the growth of pancreatic cells and tissues.RNAi has the ability of down-regulating XIAP in pancreatic cancer cells which,as a result,inhances TRAIL induced apoptosis and sensitizes the cells the chemotherapies.Small molecule XIAP inhibitors,as their names,are capable of negatively regulating XIAP,releasing what is inhibited by XIAP,increasing the apoptotic index and the sensitivity to chemotherapies.XAF1 is a novel XIAP modulator that inhibits the anti-apoptotic effects of XIAP.This review will discuss what XIAP does in the chemoresistance and treatment of pancreatic cancer.

关 键 词：X连锁凋亡抑制蛋白 胰腺癌 化疗耐药 X连锁凋亡抑制蛋白相关因子1 

分 类 号：R735.9[医药卫生—肿瘤] R730.53[医药卫生—临床医学]