3.0TMR弥散加权成像评价肝细胞癌射频消融治疗疗效  

Evaluation on the therapeutic effect of radiofrequency ablation of HCC with 3.0T MR diffusion weighted imaging

作　　者：刘于宝[1] 梁长虹[1] 张忠林[1] 王秋实[1] 谢淑飞[1] 余元新[1] 刘再毅[1] 

机构地区：[1]广东省人民医院放射科广东省医学科学院,广东广州510080

出　　处：《中国医学影像技术》2010年第5期896-899,共4页Chinese Journal of Medical Imaging Technology

基　　金：广东省医学科学技术研究基金(A2009018);广东省科技计划项目(2007B031515008)

摘　　要：目的评价3.0TMR表观弥散系数(ADC)检测射频消融治疗后肝细胞癌(HCC)变化的价值,探讨弥散加权成像(DWI)在检测HCC射频消融治疗后不同病理改变的价值。方法40例HCC患者在射频消融治疗后3～7天、2个月、6个月接受3.0TMRDWI检查,b值为600s/mm2,测量、分析射频消融治疗后病灶ADC值。结果射频消融治疗后3～7天、2个月、6个月坏死区ADC值明显降低,2个月、6个月时射频消融中心坏死区ADC值高于治疗后3～7天;3～7天与2个月、6个月时坏死组织的ADC值比较,差异均有统计学意义(P<0.01),治疗后2个月与6个月时坏死组织的ADC值差异无统计学意义(P>0.05)。治疗后3～7天、2个月、6个月时活性残留或复发肿瘤组织ADC值差异均无统计学意义(P>0.05)。结论ADC值可用于鉴别射频消融治疗HCC后坏死组织与复发或残留肿瘤组织。Objective To evaluate the value of ADC in detecting the lesions of post-radiofrequency ablation of hepatocellutar carcinoma （HCC） with 3.0T MR DWI, and the value of 3.0T DWI in detecting features of HCC. Methods Forty patients with HCC of post-radiofrequency ablation 3-7 d, 2 months, 6 months underwent 3.0T MR DWI （b=600 s/mm^2）. The ADC values of lesions pre and post-radiofrequency ablation were measured and analyzed. Results The ADC values of necrosis tissues decreased evidently in 3-7 d, 2 months, 6 months, and the values of necrosis tissues in 2 months and 6 months were higher than those of 3-7 d. There were significant differences of ADC values between 3-7 d and 2 months, as well as 3-7 d and 6 months （P〈0.01）, but no significant differences of ADC values was found between 2 months and 6 months （P〉0.05）. There was no significant difference of ADC values of tumors in the viable residue or recurrence tumor tissues among 3-7 d, 2 months, 6 months （P〉0.05）. Conclusion The ADC values of 3.0T MR DWI can be used in distinguishing the necrosis tissues and the viable residue or recurrence tumor tissues in HCC after radiofrequency ablation.

关 键 词：癌 肝细胞的 导管消融 扩散磁共振成像 

分 类 号：R735.7[医药卫生—肿瘤] R445.2[医药卫生—临床医学]