TGF-β_1介导的Smads与ERK通路在肺纤维化中的作用及相互关系  

The relationship between TGF-β_1-mediated Smads and ERK in the progression of pulmonary fibrosis

作　　者：杨雅茹[1] 黄艳[1] 李俊[1] 

机构地区：[1]安徽医科大学药学院,安徽合肥230032

出　　处：《中国药理学通报》2010年第5期561-563,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30371766;30572355);安徽省自然科学基金项目(No090413134);高等学校优秀青年人才基金重点项目(No2009SQRZ049ZD)

摘　　要：丝裂原活化蛋白激酶(MAPK)是体内四大信号转导系统之一,已发现p38、ERK5/BMK1、ERK及JNK/SAPK4个亚族。它参与介导生长、发育、分裂、分化、死亡及细胞间功能同步等多种细胞过程,其中ERK通路在肺成纤维细胞(FB)增殖过程中起着非常重要的作用。在肺纤维化(pulmonaryfibrosis)的进程中,转化生长因子β-1(TGF-β1)介导的Sma-andMAD-related(Smad)与ERK通路,通过对FB等细胞的作用、对多种炎症因子生成的调控以及促进转录因子活化等机制来调节纤维化过程的发生发展。该文就Smads和ERK通路在肺纤维化发病中的作用及两条通路之间的相互关系作一综述。Mitogen activated protein kinase（MAPK）is one of the four biggest signal transduction systems which contain four subtribes named p38,ERK5/BMK1,ERK and JNK/SAPK respectively.Previous studies have shown that MAPK pathway is involved in growth,cell differentiation,perishing,the synchronization of cell function and so on.ERK/MAPK,one of the members of MAPK family,and Sma-and MAD-related（Smad）play important roles in the proliferation of fibroblast,modulating inflammation mediator production as well as transferring factors activity in the process of pulmonary fibrosis（PF）.This review focuses on relationship between Smads and ERK in the pathogenesis and progression of PF.

关 键 词：转化生长因子Β-1 SMADS ERK 肺成纤维细胞 肺纤维化 信号转导通路 

分 类 号：R-05[医药卫生] R329.25