消痰散结方对荷S180肉瘤小鼠蛋白质代谢的影响  

Effect of Xiaotansanjie Recipe on Protein Metabolic of S180 Bearing Mice

作　　者：林晖明[1] 魏品康[1] 许玲[1] 巨大维[1] 顾坚忠[2] 白辰光[3] 

机构地区：[1]第二军医大学附属长征医院中医科,上海200003 [2]中国科学院上海实验动物中心 [3]第二军医大学附属长海医院病理科

出　　处：《肿瘤防治研究》2010年第5期525-527,534,共4页Cancer Research on Prevention and Treatment

摘　　要：目的运用荷S180小鼠模型,观察消痰散结方改善肿瘤蛋白质代谢状况的作用,探索其作用机制。方法将40只小鼠随机分为消痰散结方组(A组)、化疗(喃氟啶)组(B组)、0.9%氯化钠溶液组(C组),对照组(D组),前三组进行S180肉瘤皮下接种造模;4周后,观察各组体重,血清生化检测总蛋白、白蛋白和C-反应蛋白(CRP)水平,免疫组化观察骨骼肌结构及骨骼肌NF-κB的表达。结果消痰散结方可升高荷瘤鼠血清总蛋白、白蛋白水平,下调血清CRP水平,对骨骼肌结构具有保护作用。结论消痰散结方可以改善肿瘤蛋白代谢状况,其可能途径是通过调节肝脏的蛋白代谢。Objective To investigate the effects of Xiaotansanjie Recipe on protein metabolic of S180 bearing mice and discuss its mechanism.Methods Forty mice were randomly divided into 4 groups：XiaotanSanjie Recipe group（A group）;FT-207 group（B group）;NS group（C group）;normal group.The mice were sacrificed on the 4th week.The weights of mice were measured.Total protein,albumin and CRP of blood were detected.The expression of muscle NF-κB was analyzed by immunohistochemistry.Results Xiaotansanjie Recipe can up-regulate total protein and albumin of blood,down-regulate blood CRP in mice.It also can protect the structure of the muscle.Conclusion Xiaotansanjie Recipe adjusted the protein metabolic abnormalities in tumor-bearing mice.It might be one of the mechanism responsible for its anti-tumor effects.

关 键 词：消痰散结方 肿瘤 蛋白代谢 小鼠 

分 类 号：R73-36[医药卫生—肿瘤] R730.52[医药卫生—临床医学]