2型糖尿病患者血清叶黄素与体内氧化应激指标的关系  

Relationship between serum lutein and oxidative stress in patients with type 2 diabetes mellitus

作　　者：章清[1] 沈新南[1] 李永烶 魏延[1] 麦嘉仪[1] 

机构地区：[1]复旦大学公共卫生学院营养与食品卫生学教研室,上海200032 [2]上海市第八人民医院检验科,上海200235

出　　处：《复旦学报（医学版）》2010年第3期343-346,360,共5页Fudan University Journal of Medical Sciences

摘　　要：目的研究2型糖尿病(diabetes mellitus,DM)患者血清叶黄素含量与氧化应激反应的关系。方法检测99例2型DM患者和83例正常对照者的空腹血糖、血清总胆固醇、血清三酰甘油;血清叶黄素、β-胡萝卜素、番茄红素和维生素E含量及血清SOD、GSH-Px、MDA、IL-6含量,采用t检验、单因素相关分析、逐步多元线性回归等方法进行统计分析。结果2型DM患者组血清叶黄素、番茄红素、β-胡萝卜素、SOD、GSH-Px水平明显低于正常对照组(P<0.05),血清MDA、IL-6水平高于正常对照组(P<0.01)。血清叶黄素、番茄红素和β-胡萝卜素与血清SOD和GSH-Px的相关系数为正值(P<0.05),与MDA相关系数为负值(P<0.05),叶黄素、β-胡萝卜素与IL-6的相关系数为负值(P<0.05)。多因素分析表明,控制BMI和年龄因素后,血清叶黄素与MDA、IL-6含量呈负相关,与血清SOD、GSH-Px呈正相关(P<0.05)。结论随着2型DM患者血清叶黄素水平的增加,血清MDA、IL-6含量降低,血清SOD与GSH-Px的活性增高。提示叶黄素可能通过抑制机体的氧化应激反应,降低IL-6的表达,从而减轻IL-6水平过高所导致的负面效应。Objective To investigate the serum lutein level and oxidative stress in patients with type 2 diabetes mellitus（DM）. Methods The concentration of fasting serum glucose,triglyceride and total cholesterol,serum lutein,lycopene,β-carotene,vitamin E,and the activity of serum superoxide dismutase（SOD）,serum glutathione peroxidase（GSH-Px）,and serum malondialdehyde（MDA） level in 99 patients with type 2 diabetes and 83 healthy subjects were measured. Results Compared with the healthy subjects,the average level of lutein,lycopene,β-carotene,SOD,GSH-Px in DM group decreased significantly（P〈0.05）,the MDA,IL-6 level increased significantly（P〈0.01）.R values of Pearson correlation coefficients between serum lutein,lycopene,β-carotene and SOD and GSH-Px were positive,R values of Pearson correlation coefficients between lutein,lycopene,β-carotene and MDA were negative（P〈0.05）,R values of Pearson correlation coefficients between serum lutein,β-carotene and IL-6 were negative（P〈0.05）.The results of multiple linear regression analysis showed that after adjusted by BMI and age,lutein was negatively correlated with serum MDA and IL-6,and positively correlated with SOD and GSH-Px（P〈0.05）. Conclusions There were close relationship between the serum biomarkers indicative of oxidative stress and serum carotenoids in patients with type 2 diabetes mellitus.As serum lutein level increased,the serum MDA and IL-6 level decreased,while SOD and GSH-Px increased,which demonstrated that lutein can decrease oxidative stress,potentially decrease IL-6 expression,and alleviate the side effects of excessive IL-6 expression.

关 键 词：叶黄素 2型糖尿病 氧化应激 细胞因子 

分 类 号：R587.1[医药卫生—内分泌]