人源幼虫巨大致死性基因Hugl-1在卵巢癌组织中的表达及其临床意义  

Expression of human giant larvae-1 in ovarian cancer and its clinical significance

作　　者：张艳[1] 满晓波[1] 白辰光[1] 惠宁[1] 

机构地区：[1]第二军医大学长海医院妇产科,上海200433

出　　处：《第二军医大学学报》2010年第5期513-515,共3页Academic Journal of Second Military Medical University

摘　　要：目的探讨人源幼虫巨大致死性基因Hugl-1在卵巢癌中的表达及其临床意义。方法利用实时荧光定量RT-PCR和原位杂交技术检测31例卵巢癌组织及其相应的癌旁组织中Hugl-1 mRNA的表达量,并结合卵巢癌的临床病理特点进行分析。结果 Hugl-1 mRNA在卵巢癌组织中的表达量高于癌旁卵巢组织[(0.051±0.029)vs(0.026±0.043),P<0.01]。Hugl-1 mRNA的表达量与卵巢癌患者的年龄、血清CA125、肿瘤病理特征及临床分期无关。结论 Hugl-1在卵巢癌的发生发展中起着一定作用。Objective To study the expression of human giant larvae-1 （Hugl-1） in ovarian carcinoma and its clinical significance.Methods Hugl-1 mRNA expression in 31 ovarian cancer and the corresponding adjacent tissues was examined by real time fluorescence quantitative RT-PCR and in situ hybridization.Moreover,analysis was done while taking into consideration of the clinicopathologic parameters of ovarian cancer.Results The expression of Hugl-1 mRNA in ovarian cancer tissue was significantly higher than that in the corresponding adjacent tissues （[0.051 ± 0.029]vs [0.026 ± 0.043],P 0.01）;and the expression was not related to patient age,serum CA125 status,pathological characteristics or clinical stages of tumors.Conclusion Hugl-1 may play a role in the development and progresssion of ovarian cancer.

关 键 词：卵巢肿瘤 人源幼虫巨大致死基因 基因表达 原位杂交 

分 类 号：R737.31[医药卫生—肿瘤]