SOX4基因的表达与肝癌术后早期复发及其临床意义  

Expression of SOX4 gene and early recurrence of hepatocellular carcinoma: their relationship and the clinical significance

作　　者：郑江华[1,2,3] 简志祥[2,3] 金浩生[2,3] 陈斯聪[2,3] 王广义[1] 

机构地区：[1]吉林大学第一医院肝胆胰外科吉林,吉林长春130021 [2]广东省人民医院 [3]广东省医学科学院肝胆胰外科,广东广州510080

出　　处：《南方医科大学学报》2010年第4期818-819,822,共3页Journal of Southern Medical University

基　　金：广东省科技计划项目(2006B36002003);广东省医学科研基金项目(A2007042)

摘　　要：目的探讨SOX4基因的表达与肝癌术后早期复发及其临床意义。方法应用免疫组化技术研究SOX4基因在30例术后早期复发肝癌、30例非术后早期复发肝癌和30例正常肝脏组织的表达。结果SOX4基因在肝癌中的表达高于正常肝组织(41.7%vs16.7%,P<0.05),SOX4基因在术后早期复发肝癌的表达高于非术后早期复发肝癌(56.7%vs26.7%,P<0.05),SOX4基因的表达与患者的性别、年龄、肿瘤直径、乙肝表面抗原、Edmonson分级无关(P>0.05)。结论SOX4基因与肝癌的术后早期复发密切相关,SOX4基因高表达有可能促进了肝癌的早期复发,并可以作为肝癌判断预后的分子指标之一。Objective To explore the relationship between the expression of SOX4 gene and early recurrence of hepatocellular carcinoma （HCC） after curative resection.Methods SOX4 expression was detected immunohistochemically in 60 HCC patients including 30 with and 30 without early recurrence after curative resection,with 30 normal liver specimens as the control.Results The expression of SOX4 was significantly higher in HCC than in normal liver （41.7% vs 16.7%,P0.05）,and in HCC tissues,the expression was significantly higher in early recurrent HCC after curative resection than in HCC without early recurrence （56.7% vs 26.7%,P0.05）.SOX4 expression was inversely correlated to the patients＇ gender,age,tumor size,HBsAg,and Edmonson grade （P0.05）.Conclusion SOX4 is closely associated with early recurrence of HCC after curative resection,and its overexpression may contribute to early recurrence of HCC.SOX4 may serve as a new molecular indicator for evaluating the prognosis of HCC.

关 键 词：SOX4 肝癌 早期复发 免疫组化 

分 类 号：R735.7[医药卫生—肿瘤]