儿童重型β-地中海贫血异基因造血干细胞移植后出血性膀胱炎的影响因素分析  

Analysis of the risk factors for hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation for beta-thalassemia in children

作　　者：伊文芳[1] 裴夫瑜[1] 吴学东[1] 刘四喜[2] 何岳林[1] 廖建云[1] 李娜[1] 陈戈煜[1] 冯晓勤[1] 李春富[1] 

机构地区：[1]南方医科大学南方医院儿科,广东广州510515 [2]深圳市儿童医院血液科,广东深圳512080

出　　处：《南方医科大学学报》2010年第4期838-841,共4页Journal of Southern Medical University

摘　　要：目的探讨儿童重型β-地中海贫血(重型地贫)异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation,Allo-HSCT)后出血性膀胱炎(HC)的影响因素。方法对我院儿科造血干细胞移植中心2008年12月～2009年11月儿童重型地贫Allo-HSCT33例病例,进行回顾性分析。结果HC发病率为24.24%(8/33),其中Ⅰ度1例,Ⅱ度6例,Ⅲ度1例。HC的中位时间为22.9(6～35)d,持续的中位时间为11.9(3～27)d。年龄影响HC的发病率(P=0.042,P<0.05);年龄≥6岁的儿童发病率明显高于年龄<6岁儿童。结论儿童重型地贫Allo-HSCT,年龄是HC的主要影响因素。Objective To analyze the risk factors of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation for beta-thalassemia in children.Methods The clincial records of 30 children with beta-thalassemia undergoing allogeneic hematopoietic stem cell transplantation between December,2008 and November,2009 were analyzed.Results Hemorrhagic cystitis occurred in 8 of the 33 patients with an incidence of 24.24%,including 1 with grade I,6 with grade II and 1 with grade III hemorrhagic cystitis.The median time of hemorrhagic cystitis onset was 22.9 days （range 6-35 days） and the median duration was 11.9 days （range 3-27 days）.Univariate analysis indicated that the different types of transplantation and acute graft-versus-host disease affect the occurrence of hemorrhagic cystitis.The children with Allo-PBSCT had higher incidence than those receiving Allo-PBSCT＋Allo-UBT and Allo-BMT （P0.05）.The children at an age ≥6 years had obviously higher incidence of hemorrhagic cystitis than those at younger ages.Conclusion Age is the major factor that affects the occurrence of hemorrhagic cystitis in children undergoing allogeneic hematopoietic stem cell transplantation for beta-thalassemia.

关 键 词：异基因 造血干细胞移植 出血性膀胱炎 影响因素 儿童 Β-地中海贫血 

分 类 号：R725.5[医药卫生—儿科]