氟西汀联合心理干预治疗心血管疾病伴焦虑抑郁的临床研究  

A Clinical Study of Fluoxetine Plus Mental Intervention in Cardiovascular Disease with Anxiety and Depression

作　　者：夏南[1] 范文澜[1] 王海燕[1] 

机构地区：[1]南充市精神卫生中心神经内科,四川南充637000

出　　处：《华西医学》2009年第10期2511-2513,共3页West China Medical Journal

摘　　要：目的:探讨氟西汀联合心理干预治疗心血管疾病患者伴焦虑抑郁症状的临床疗效。方法:选择伴有抑郁、焦虑情绪障碍的85例冠心病患者(心功能Ⅱ、Ⅲ级),并将其随机分成研究组和对照组。观察6w,对照组患者仅给予常规的治疗,研究组患者在常规治疗基础上给予氟西汀联合心理干预治疗。观察治疗前后两组患者采用汉密顿焦虑量表(Hamilton Anxiety Scale,HAMA)评定焦虑症状,汉密顿抑郁量表(Hamilton Depression Scale,HAMD)评定抑郁症状;并对治疗后心功能分级(NYHA)恢复到Ⅰ级的例数及左室射血分数进行分析评价。结果:治疗6周后,研究组均较对照组的汉密顿焦虑量表及汉密顿抑郁量表评分下降显著(P<0.01),研究组抗焦虑显效率为87.16%、抗抑郁显效率为82.26%,对照组分别为43.75%、45.36%,研究组均显著高于对照组(P<0.01);研究组患者的左室射血分数显著高于对照组(P<0.05),心功能分级(NYHA)恢复到Ⅰ级的例数显著高于对照组(P<0.05)。结论:氟西汀联合心理干预治疗不仅能改善心血管疾病伴焦虑抑郁患者的焦虑、抑郁情绪障碍,还能改善患者的心功能,疗效显著优于单用心血管药物治疗。Objective：To explore the clinical efficacy of fluoxetine plus mental intervention in the treatment of cardiovascular Disease（CVD） with anxiety and depression.Methods：Eighty-five anxiety and depression patients with CVD were randomly divided into research group （n = 40） receiving fluoxetine plus psychotherapy and control group （ n = 45） doing routine cardiovascular drugs for 6 weeks.Anxiety and depression were eluvated by the Hamilton Anxiety Scale （HAMA） and Hamilton Depression Scale （HAMD）,cardiac function by NYHA,and left ventricularejection fraction by Echo-Doppler.Results：Research group compaired with control group,the scores of HAMA and HAMD decreased significantly （P〈0.01）,the left ventricularejection fraction elevated significantly （P〈0.05）,and the number of recover to cardiac function classⅠincreased significantly（P〈0.05）.Conclusion：After fluoxetine plus mental intervention in CVD with anxiety and depression,anxiety and depression symptoms and cardiac dysfunction were all improved,the efficacy was significantly superior to single-use cardiovascular medication.

关 键 词：抗抑郁剂 心理干预 心血管疾病 焦虑抑郁 

分 类 号：R749.2[医药卫生—神经病学与精神病学]