血清CA15-3和B-AKP检测在乳腺癌骨转移显像诊断中的应用  

The Application of Serum CA15-3 and B-AKP Measurements in Bone Scanning for Metastasis in Patients with mammary Cancer Diagnostic

作　　者：刘雁[1] 张霞[1] 袁士强[1] 

机构地区：[1]聊城市第二人民医院核医学科,山东聊城252600

出　　处：《华西医学》2009年第11期2887-2889,共3页West China Medical Journal

摘　　要：目的:探讨血清CA15-3和B-AKP在乳腺癌骨转移显像诊断中的应用。方法:对92例乳腺癌患者的核素骨显像结果、血清CA15-3和B-AKP结果进行回顾性研究。结果:①血清CA15-3和B-AKP的值随着骨转移分期的增高而逐步升高,且差异显著(P<0.01);②血清CA15-3和B-AKP与骨转移的数目呈正相关;③血清CA15-3>25U/mL时,骨转移的阳性率为63.3%,血清CA15-3<25 U/mL时,骨转移的阴性预测值为94.5%;血清B-AKP>20U/L时,骨转移的阳性率为59.6%时,骨转移的阴性预测值为73.5%;当血清CA15-3<25 U/mL同时B-AKP<20U/L时,骨转移的阴性预测值为100%。结论:血清CA15-3和B-AKP测定在乳腺癌骨显像诊断中具有重要的应用价值。Objective：To evaluate the diagnosis value of serum CA15-3 and B-AKP measurements for scanning bone metastatic images in patients with mammary Cancer.Methods：Retrospective study on the bone scan images and serum CA15-3（with CLIA） and bone alkaline phosphatase（B-AKP,with ELISA） levels were performed in 92 patients with confirmed mammary gland cancer.Results：①The serum levels of CA15-3 and B-AKP were increased step by step along with the advancement of bone metastatic grading from M0 to M3 with significant difference between values in successive gradings（P0.01）.②The levels of CA15-3 and B-AKP were significantly positively correlated.③With serum CA15-325 U/mL the positive rate of bone metastasiswas 63.2%,with CA15-325 U/mL the negative predictive value of bone metastasis was 94.5%,with B-AKP20 U/L,the positive rate of bone metastasis was 59.6%,with B-AKP20 U/L,the negative predictive value of bone metastasis was 73.5%.However with Serum CA15-325 U/mL and B-AKP20 U/L,the negative predictive value of bone metastasis was100%.Conclusion： The combined measurement of the serum CA15-3 and B-AKP levels would play an important role for diagnosis of bone scan images in patients with prostate cancer.

关 键 词：乳腺癌 骨转移 骨显像 乳腺癌糖类抗原153 骨特异性碱性磷酸酶 

分 类 号：R737.9[医药卫生—肿瘤] R817.4[医药卫生—临床医学]