胚胎干细胞分化为胰腺内分泌细胞的主要转录因子及其相关机制  

Main transcription factors and related mechanisms of embryonic stem cells differentiation into pancreatic endocrine cells

作　　者：郑扬[1,2] 周作红[1] 侯玲玲[3] 李方华[2] 关伟军[2,4] 马月辉[2] 

机构地区：[1]江西农业大学动物科学技术学院,江西省南昌市330045 [2]中国农业科学院北京畜牧兽医研究所,北京市100193 [3]北京交通大学生命科学与生物工程研究院,北京市100044 [4]山西农业大学动物科技学院,山西省太谷县030801

出　　处：《中国组织工程研究与临床康复》2010年第19期3573-3577,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科科学基金项目(30671539);“863”高新技术发展计划(2007AA10Z170)~~

摘　　要：背景:胰岛内分泌细胞,尤其是分化为胰岛β细胞,为解决糖尿病的胰岛供体短缺提供有效途径。目的:文章将对胚胎干细胞分化为胰腺内分泌细胞过程中参与的主要转录因子及其相关机制进行概述,为治疗糖尿病奠定理论基础。方法:由第一作者于2009-09应用计算机检索PubMed数据库相关文献。检索时间范围:1997/2009。检索关键词为"Embryonicstemcells;Transcriptionfactors;Pancreaticendocrinecells"。纳入与胚胎干细胞分化为胰腺内分泌细胞的主要转录因子及其相关机制研究相关的内容。排除重复文献。阅读标题和摘要进行筛选,共纳入32篇用于综述。结果与结论:胰腺内分泌细胞是胰腺的主要分泌部位,可分泌胰高血糖素、胰岛素、生长抑素、胰多肽和胃促生长素等,这些激素在调节血糖浓度中有着重要作用。胚胎干细胞是一种多潜能干细胞,可分化为胰腺内分泌细胞,在分化过程中受到多种基因和转录因子的调控参与,但目前人们对转录因子的研究仅局限于单个转录因子,对于胰腺发生发育过程中的调节网络研究还需要进一步深入和完善。BACKGROUND：Islet endocrine cells to address the shortage of donor islet diabetes provide an effective way,which differentia into islet β cells.OBJECTIVE：To summary main transcription factors and relevant mechanisms during differentiation of embryonic stem cells（ESCs） into pancreatic endocrine cells,and to provide theoretical basis for treating diabetes mellitus.METHODS：The first author retrieved PubMed database in computer for relevant literatures published from 1997 to 2009 in September 2009.The Keywords were ＂Embryonic stem cells;Transcription factors;Pancreatic endocrine cells＂.Studies concerning main transcription factors and relevant mechanisms during differentiation of ESCs into pancreatic endocrine cells were included.Duplicated studies were excluded.Following screening titles and abstracts,32 articles were included. RESULTS AND CONCLUSION：Pancreatic endocrine cells are the major secretory sites of pancreas.They can secrete glucagon,insulin,somatostatin,pancreatic polypeptide and ghrelin,which make an important role in the regulation of blood glucose concentration.ESCs are a kind of multipotential stem cells,can differentiate into pancreatic endocrine cells with regulation of many genes and transcription factors involved in the process.However,present studies only focused on single transcription factor,and we should do further investigations on network regulation during occurrence and development of pancreas.

关 键 词：胚胎干细胞 转录因子 胰腺内分泌细胞 干细胞 综述文献 

分 类 号：R394.2[医药卫生—医学遗传学]