模型鼠低氧预适应适宜氧气浓度研究  

Suitable oxygen concentration for rat model's hypoxic preconditioning

作　　者：胡定煜[1,2] 李浡[3] 戴荣继[1] 耿利娜[1] 邓玉林[1] 

机构地区：[1]北京理工大学生命科学与技术学院,北京100083 [2]中国人民武装警察部队学院,河北廊坊065000 [3]北京电子科技职业学院,北京100029

出　　处：《中国应用生理学杂志》2010年第2期137-141,共5页Chinese Journal of Applied Physiology

基　　金：国防科学技术工业委员会合作项目(A2220060042);国家自然科学基金资助项目(20705005)

摘　　要：目的:研究低氧预适应训练的适宜氧气浓度。方法:设计了短期和长期两种间歇性低氧暴露模式,研究了一系列不同浓度的低氧环境对模型鼠体重、血氧饱和度、游泳能力等方面的影响,进而探讨低氧预适应效应与氧气浓度之间的内在联系。结果:模型鼠长期暴露于低氧环境中,其体重增长率逐步下降;在15%～8%的低氧浓度区间,模型鼠血氧饱和度随氧气浓度降低呈现平台似缓慢下降趋势;低氧预适应训练后的模型鼠游泳能力显著提高,经在10%低氧环境中进行低氧预适应训练后的昆明小鼠游泳能力提高最为明显。结论:适当浓度的低氧预适应训练可以改善模型鼠低氧耐受能力,显著提高模型鼠运动能力。15%～10%氧气浓度区间可视为低氧预适应有益作用区间。10%氧气浓度为模型鼠低氧预适应训练的较适宜浓度。Objective：To study the suitable oxygen concentration in hypoxic preconditioning.Methods：Short-term and long-term intermittent hypoxia modes were designed and the effects of various oxygen concentrations on body weight,blood oxygen saturation,swimming capability were analyzed.Results：The rate of body weight gain in rat model decreased gradually when exposed to hypoxia environment for long time.When the concentration of oxygen changed from 15% to 8%,accompanied with the decreasing of oxygen concentration,a platform was observed in blood oxygen saturation of rat model after hypoxic preconditioning training.Rat swimming capability improved significantly.After trained in 10% hypoxia environment,the swimming capability of kunming mice improved obviously.Conclusion：Proper level of hypoxic preconditioning training could improve hypoxia tolerance and enhance the rat sport capability significantly.15%～10% oxygen concentration range could be regarded as a helpful effective area for hypoxic preconditioning,10% oxygen concentration might be the eligible concentration for hypoxic preconditioning training.

关 键 词：低氧预适应 低氧 模型鼠 

分 类 号：X912[环境科学与工程—安全科学]