孕期低氧应激对子代雄性大鼠性行为的影响  

The effects of hypoxia during pregnancy on sexual behavior of male offspring

作　　者：潘安卿[1] 章丽梅[1] 胡健饶[1] 

机构地区：[1]杭州师范大学生命与环境科学学院,浙江杭州310036

出　　处：《中国应用生理学杂志》2010年第2期182-186,共5页Chinese Journal of Applied Physiology

基　　金：国家973计划资助项目(2008CB117015);浙江省科技厅重点资助项目(2008C22049);宁波市科学技术规划局资助项目(2007C10081)

摘　　要：目的:研究孕期低氧应激对子代雄性大鼠的繁殖行为及相关激素分泌的影响。方法:实验将配对获得的怀孕第14天的母鼠随机分为3组:对照组(Control)、3300m模拟高原低氧应激组和5000m模拟高原低氧应激组,实验组母鼠放入低氧舱中进行持续7天的模拟低氧应激处理,对照组在实验条件下常规饲养。结果:孕期经低氧应激子代雄性性成熟个体具有与雌性个体交配的能力,但是行为能力有不同程度的下降。同时,应激组个体肛阴距变短,血浆睾酮水平下降而皮质酮水平显著升高,而3组动物睾酮、附睾以及肾上腺指数间无显著差异。结论:出生前受到低氧应激对子代雄性个体的性行为能力产生持久的抑制影响。Objective：To investigate the effects of hypoxia during the prenatal period and its later repercussions on sexual behavior and the sex hormone secretion of male rats.Methods：Experimental animals were divided into three groups randomly：control group,which was kept at normal atmospheric pressure,and two stress groups exposed to a simulated altitude equivalent to 3 000 m and 5 000 m,respectively.Stress groups were exposed to hypoxic circumstance at their final week of gestation in animal decompression chamber.Results：Adulthood,males exposed to hypoxic stress during the prenatal period were able to mate with normal females,but these treated males exhibited decreased male sexual behavior.Decreased anogenital distances were observed in male offspring,and presented reductions of plasma testosterone levels,increase of plasma corticosterone levels,but no notable alteration in the organ index.Conclusion：These results indicate that exposure to hypoxia in the later stages of pregnancy may have a long-term effect on the fertility and sexual behavior of male offspring.

关 键 词：孕期低氧 子代雄性大鼠 性行为 

分 类 号：Q492[生物学—生理学] R364.4[医药卫生—病理学]