血清肿瘤标志物联合检测在肺癌诊断中的临床价值  

Diagnostic Value of Combined Detection of Tumor Marker CEA,CA125,NSE and CYFRA21-1 in Patients with Lung Cancer

作　　者：夏武[1] 门莉[1] 

机构地区：[1]九江学院附属医院呼吸内科,江西九江332000

出　　处：《实用临床医学（江西）》2010年第5期1-2,8,共3页Practical Clinical Medicine

摘　　要：目的探讨肿瘤标志物癌胚抗原(CEA)、糖类抗原125(CA125)、神经特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)检测对肺癌诊断的临床价值。方法收集肺癌患者92例和肺良性疾病患者60例,用电化学发光法检测其血清中CEA、CA125、NSE和CYFRA21-1的阳性率。结果肺癌患者血清肿瘤标志物阳性率明显高于肺良性疾病患者,差异有统计学意义(均P<0.01),CEA、CA125在肺腺癌中、NSE在小细胞肺癌中、CY-FRA21-1在肺鳞癌中阳性率最高(分别为67.4%、67.4%、70.6%和74.3%)。四者联合检测可提高阳性率至88.8%,显著高于各单项肿瘤标志物的敏感性。结论肿瘤标志物联合检测可提高肺癌检测的敏感性,具有一定的临床应用价值。Objective To investigate the clinical value of serum CEA,CA125,NSE and CYFRA21-1 in the diagnosis of lung Cancer.Methods Serum CEA,CA125,NSE and CYFRA21-1 were measured with electrochemiluminescence immunoassay method in 98 patients with lung cancers,60 patients with benign lung diseases.Results Serum tumor markers in the lung cancer patients were higher than in the benigh lung disease patients,showing statistically significant differences（all P0.01）.CEA and CA125 had the highest sensitivity（67.4%,67.4%） for detecting adenocarcinoma.NSE had the highest sensitivity（70.6%） for detecting small cell lung cancers（SCLC）.CYFRA21-1 had the highest sensitivity（74.3%） for detecting squamous carcinoma.The combination of four serum tumor markers had higher sensitivity（88.8%） than the single marker for the diagnosis of lung cancers.Conclusion Serum CEA,CA125,NSE and CYFRA21-1 are helpful markers for the diagnosis of lung cancer.The combination of the markers can improve the sensitivity of the diagnosis.

关 键 词：肿瘤标志物 肺癌 诊断 

分 类 号：R734.2[医药卫生—肿瘤]