放疗热疗化疗综合治疗非小细胞肺癌  

Radio-thermo-Chemotherapy comprehensive treatment for lung cancer

作　　者：周桂霞[1] 崔书祥[1] 常庆森[1] 赵陆军 赵彼得[1] 郭新娜[1] 

机构地区：[1]解放军总医院放疗科

出　　处：《中华理疗杂志》1999年第1期7-9,共3页Chinese Journal of Physical Therapy

摘　　要：目的：通过放疗、热疗和化疗的不同组合，寻求综合治疗中、晚期非小细胞肺癌的最佳方法。方法：随机分为三组，放热化综合治疗组２８例，放热治疗组２３例，单纯放疗组２７例；鳞癌６３例，腺癌１４例，类癌１例。采用８ＭＨｚ射频热疗机，常规放射治疗方法，每次１．８～２．０Ｇｙ，每周５次，肿瘤剂量（ＤＴ）５０～７０Ｇｙ。放疗后３０～６０分钟内热疗，持续６０分钟，肿瘤内温度４１～４３℃，每周２次，８～１２次为１疗程。化疗在放疗后、热疗前或热疗中进行，每周１次。结果：总有效率和２年生存率放热化疗组为７１％和５４％，放热疗组为７４％和６１％，单放组为５２％和４１％，χ２检验Ｐ＞０．０５。死亡３８例，其中包括失访１２例，死亡原因为远处转移１７例，局部复发９例。结论：综合治疗组无论是总有效率或是２年生存率均优于单放组，虽无统计学意义。Objective:To explore the effect of this comprehensive treatmnt on lung cancer and their different optimal matched method. Methods:78 lung cancer patients(the squarmous carcinoma 63,adenocarcinoma 14,carcinoid 1) were randomly divided into three groups: The radio-thermo-chemotherapy comprehensive group was 28 cases,the radio-thermotherapy 23 and only radiotherapy 27.The radiation dose in radiotherapy group was 60-70Gy,the other two groups 50-60Gy commonly.The thermotherapy was performed twice a week,60min,for 8-12 times after the radiotherapy.The tumor temperature reached 41-43℃.The chemotherapy was performed between the radio-and thermotherapy,once a week .The drug of PDD,VCR,CTX and ADM was selected.The chest CT was measured and compared before and after the treatment.Results:The effective rate and survival rate of 2 years in radio-thermo-chemotherapy group were respectively 71% and 54%, the radio-thermotherapy group 74% and 61%, the radio-therapy group 52% and 41%.There was a difference(P<0.05) among them.Conclusion:According to the near result and survival rate of 2 years,the effects of comprehensive treatment are surperior to those of only radiotherapy.But the far-effects will be further observed.

关 键 词：肺癌 放射疗法 温热疗法 药物疗法 非小细胞肺癌 

分 类 号：R734.205[医药卫生—肿瘤] R730.5[医药卫生—临床医学]