不同水温下游泳应激对小鼠开场行为及学习记忆能力的影响  

Effect of Swimming Stress in Water of Different Temperature on Behaviorof Open Field,Learning and Memory in Mice

作　　者：张小虎[1,2,3] 田苏平[1,2,3] 马红[1,2,3] 周广旭[1,2,3] 孙秀兰[1,2,3] 陈启盛[1,2,3] 

机构地区：[1]南京医科大学生理教研室 [2]江苏职工医科大学 [3]南京大学生物科学与技术系

出　　处：《基础医学与临床》1999年第1期53-55,共3页Basic and Clinical Medicine

基　　金：江苏省教委自然科学基金

摘　　要：目的研究不同强度的应激刺激对小鼠开场行为和学习记忆能力的影响。方法通过使用不同水温（１２、１８及２５℃）下游泳１５ｍｉｎ作为不同强度的应激刺激。观察小鼠开场行为（Ｏｐｅｎｆｉｅｌｄ）以及Ｙ－迷宫分辨学习能力和跳台试验中记忆保持能力的变化。结果各游泳组的自发活动增加，探究行为无变化；１８和２５℃游泳组的学习记忆能力有显著提高，１２℃游泳组有所降低。结论不同温度下的游泳应激均可增加小鼠的探究活动，但应激刺激过于强烈会降低小鼠的学习记忆能力，适当强度的应激刺激能提高小鼠的学习记忆能力。Objective To evaluate the effect of stress at different intensity on the behaviour of Open field,learning and memory of mice.Methods Open field,Y-maze test and step-down test have been carriedout in four group:control (C)and groups with swimming in water of 12,18 and (S1,S2, S3).Results Ambulation of all swimming group increased significantly.Behaviour of exploration wasnot changed.Groups of swimming at 18 and 25 have a significnt increase in the ability oflearning and memory,by contrast,the group of 12 was decreased.Conclusions Swimmingstress in different temperature can increase ambulation of mice.But strong stress may impair learn-ing and memory of mice,stress at proper intensity could increase the ability of learning and memoryof mice.

关 键 词：应激刺激 游泳 水温 开场行为 学习记忆 

分 类 号：R363.271[医药卫生—病理学] R338.64[医药卫生—基础医学]