百忧解治疗脑卒中后抑郁的疗效观察  

The effect of Prozac 64 cases with poststroke depression

作　　者：段武钢[1] 祝峰[1] 高作咏[1] 汪红凡[1] 

机构地区：[1]湖北省咸宁学院附属第二医院,湖北咸宁437100

出　　处：《中国民康医学》2010年第11期1360-1361,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨百忧解治疗脑卒中后抑郁的临床效果。方法:将128例脑卒中后抑郁患者随机分为观察组和对照组,在对照组常规药物治疗的基础上,观察组加用百忧解治疗。8周后,对两组患者进行HAMD、MESSS、TESS评分。结果:经过治疗,观察组的脑卒中后抑郁的显效率为75.0%,神经功能恢复总有效率为92.2%,均显著高于对照组的46.9%和67.2%(P<0.01);治疗后两组的HAMD和MESSS评分均显著下降(P<0.05或P<0.01),两组间比较差异有统计学差别(P<0.01);TESS评分没有差异(P(0.05)。结论:百忧解治疗脑卒中后抑郁具有疗效高、不良反应小等优点,值得临床推广。Objective：To evaluate the effect of Prozac for patients with poststroke depression. Methods ：128 cases with posts- troke depression were randomly divided into observe group and control group. Observe group was treated by Prozac on the base of con- trol group. Patients were assessed before and after treatment by HAMD , MESSS and TESS. Results： After 8 weeks treated, observe group＇s total effective rates of poststroke depression and nerves functional restoration was 75.0% and 92.2%. They are highly than control group significantly（ P 〈 0.01 ） ,and significant differences were found between two groups in total scores of HAMD and MESSS （P 〈 0.01 ） , though there were a significant drop in each group （P 〈 0.05 or P 〈 0.01 ）. No difference was found between two groups in total scores of TESS（P 〉 0.05）. Conclusions： Prozac in treatment of poststroke depression has high efficacy and few side effects, worth to spread clinical.

关 键 词：百忧解 脑卒中后抑郁 疗效 

分 类 号：R749.13[医药卫生—神经病学与精神病学]