度洛西汀与西酞普兰治疗老年抑郁症的对照研究  

Comparative study of Duloxetine and Citalopram in the treatment of senile depression

作　　者：吴延海[1] 向秀珠 吴伟娟 唐思源[1] 邵建峰[1] 何震[1] 

机构地区：[1]安徽省荣军医院,安徽怀远233400 [2]广东省韶关市乐昌复退军人医院

出　　处：《中国民康医学》2010年第11期1367-1367,1369,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:比较度洛西汀和西酞普兰治疗老年抑郁症的疗效及安全性。方法:对66例老年抑郁症患者随机分为度洛西汀组和西酞普兰组,疗程6周。采用汉密尔顿抑郁量表(HAMD)和治疗中出现的症状量表(TESS)在治疗前及治疗1、2、4、6周评定疗效和不良反应。结果:两组治疗后各时段HAMD评分均较治疗前明显下降(P均(0.01)。两组疗效差异无统计学意义(P>0.05)。两组不良反应比较无显著性差异(P>0.05)。结论:度洛西汀是一种安全有效的抗抑郁药,可用于老年抑郁症患者。Objective：To compare the efficacy and safety of Duloxetine and Citalopram in the treatment of senile depression. Methods ：66 patients with senile depression were randomly divided into Duloxetine group and Citalopram group for 6 week treatment. Hamilton depression scale （HAMD） and treatment emergent symptom scale （TESS） were used to evaluate the clinical efficacy and safety, before treatment and 1, 2, 4,6week after treatment. Results： The score of HAMD reduced significantly after every treatment time in two groups （both P 〈 0.01 ）. There were no significant differences in the efficacy and adverse events between the two groups. Conclusions： Duloxetine is an effective and safe antidepressant in the treatment of senile depression.

关 键 词：度洛西汀 西酞普兰 老年抑郁症 

分 类 号：R749.41[医药卫生—神经病学与精神病学]