ATP-TCA在大肠癌化疗药物敏感性检测中的应用  

Application of Adenosine Triphosphate-Tumor Chemosensitivity Assay in Breast Cancer Chemotherapy

作　　者：戴晓宇[1] 李克强[1] 杨峂[1] 毛联钢[1] 乐东海[1] 冯伟云[1] 

机构地区：[1]浙江省宁波市第二医院,宁波315000

出　　处：《浙江中西医结合杂志》2010年第6期341-343,共3页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

基　　金：宁波市医学科技重点项目资助(No.2006004)

摘　　要：目的:评估ATP-TCA肿瘤药敏检测法指导制定大肠癌化疗方案的可行性。方法:应用ATP-TCA肿瘤药敏检测法,检测28例大肠癌手术标本和19例大肠癌外周血标本对8种常用抗肿瘤药物的敏感性。结果:大肠癌对抗癌药物的敏感程度存在着异质性,联合用药的敏感率高于单药。外周血标本和手术标本检测结果具有一致性,检测结果与临床疗效基本相符。结论:ATP-TCA肿瘤药敏检测法可用于临床制定大肠癌个体化的化疗方案。Objective：To evaluate the feasibility of adenosine triphosphate（ ATP）-tumor chemosensitivity assay （TCA） in order to guide individualized chemotherapy for colorectal cancer. Methods：The ATP-TCA was used to detect sensitivity of 8 conventional antieancer drugs in 28 surgical specimens and 19 peripheral blood samples harvested from colorectal cancer patients. Results： The drug sensitivity existed heterogeneity, and combination therapy possessed higher sensitivity than monotherapy did. The test results of peripheral blood samples and surgical specimens had a certain consistency,which was also consistent with clinical efficacy. Conclusion：ATP-TCA can be used clinically to develop individualized chemotherapy for coloieetal cancer program.

关 键 词：大肠癌 肿瘤药敏检测法 化疗方案 

分 类 号：R735.34[医药卫生—肿瘤]