消化性溃疡抑酸治疗对随后根除幽门螺杆菌疗效的影响  

Influence of acid suppression therapy on efficacy of followed helicobacter pylori eradication

作　　者：斯锞[1] 杨杰[1] 廖文[1] 

机构地区：[1]成都市第一人民医院消化内科,四川成都610014

出　　处：《四川医学》2010年第5期615-616,共2页Sichuan Medical Journal

摘　　要：目的观察抑酸治疗对幽门螺杆菌(H.pylori)阳性消化性溃疡患者随后根除H.pylori的疗效影响。方法纳入80例急性上消化道出血、抑酸治疗1周后出血停止的H.pylori阳性消化性溃疡患者。随机分为A、B两组。A组随即给予根除H.pylori治疗[埃索美拉唑(E)20mg,2次/d,+克拉霉素(C)500mg,2次/d,+阿莫西林(A)1.0g,2次/d,共10d],再以E 20mg,2次/d,维持6周,B组采用E 20mg,2次/d治疗6周,停药2周后再予根除H.pylori。两组均停药4周后复查H.pylori,观察H.pylori根除率。结果 73例完成实验。H.pylori根除率:A组65.8%,B组88.6%,差异有统计学意义(P<0.05)。结论抑酸治疗后随即根除H.pylori疗效可能降低,应予停抑酸药物2周后再根除H.pylori。Objective To observe the influence of acid suppression therapy on the efficacy of followed helicobacter pylori（H.pylori）eradication in H.pylori positive peptic ulcer.Methods Eighty upper gastrointestinal tract hemorrhage happened and then ceased by 1 week acid suppression therapy patients diagnosed as peptic ulcer with H.pylori infection were included and randomly divided into two groups.A group received H.pylori eradication therapy：esomeprazole（E）20mg bid,clarithromycin（C）500mg bid and amoxicillin（A）1.0g bid for 10 days,and followed with E 20mg bid for 6 weeks.B group was administered with E 20mg bid for 6 weeks and no drugs 2 weeks,then received H.pylori eradication therapy.H.pylori was tested 4 weeks later after treatment.Results Seventy-three patients completed the study.The H.pylori eradication rates：A group was 65.8%,B group was 88.6%.The difference was significant（P0.05）.Conclusion The efficacy of H.pylori eradication followed acid suppression therapy may be decreased,it may be started 2 weeks later after acid suppression therapy.

关 键 词：幽门螺杆菌 根除 疗效 

分 类 号：R573.1[医药卫生—消化系统]